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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Mo, Yiwen Li, Yongjiang Huang, Yuqian Chen, Mingshi Zhou, Chao Li, Xinling Wei, Yuan Li, Ruping Fan, Wei Zhang, Xu |
| Abstract | Background The metabolic response of primary central nervous system lymphoma (PCNSL) patients has yet to be evaluated. This study aimed to assess the prognostic value of a novel scoring scale, the intracranial metabolic score (IMS), in PCNSL patients receiving end-of-therapy 18F-FDG PET/CT (EOT-PCT) and PET/MR (EOT-PMR). Methods The IMS was determined based on the metabolism of normal intracranial structures, including gray matter, white matter, and cerebrospinal fluid. The EOT-PCT cohort was evaluated using the IMS and commonly used Deauville score (DS). Another cohort of patients who underwent the EOT-PMR was used to validate the accuracy of the IMS. Results In total, 83 patients were included in the study (38 in PET/CT cohort, and 45 in PET/MR cohort). The area under the curve (AUC) values of the IMS for predicting PFS and OS were superior to those of the DS. When patients in the PET/CT cohort were stratified into five groups (respectively labeled IMS 1–5), three groups (IMS1-2, IMS 3–4, and IMS 5), or two groups (IMS1-3 and IMS4-5; IMS 1–4 and IMS 5), a higher IMS score was significantly correlated with poorer PFS and OS (p < 0.001). Similar results were observed for PFS in the PET/MR cohort (p < 0.001). The IMS and DS scale were found to be independent prognostic indicators for PFS and OS in the PET/CT cohort, and the IMS was identified as the sole independent prognostic indicator for PFS in the PET/MR cohort. Conclusion The IMS as a novel and effective prognostic tool for PCNSL patients, showing superior predictive value for patients’ outcomes compared to the DS when assessed with EOT-PET scans. |
| Related Links | https://cancerimagingjournal.biomedcentral.com/counter/pdf/10.1186/s40644-024-00798-1.pdf |
| Ending Page | 14 |
| Page Count | 14 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14707330 |
| DOI | 10.1186/s40644-024-00798-1 |
| Journal | Cancer Imaging |
| Issue Number | 1 |
| Volume Number | 24 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-11-11 |
| Access Restriction | Open |
| Subject Keyword | Oncology Cancer Research Imaging Radiology Nuclear Medicine 18F-FDG Primary central nervous system lymphoma PCNSL PET/MR PET/CT Deauville score |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiological and Ultrasound Technology Radiology, Nuclear Medicine and Imaging Oncology |
| Journal Impact Factor | 3.5/2023 |
| 5-Year Journal Impact Factor | 4.3/2023 |
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