NDLI: Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease

Content Provider	Springer Nature : BioMed Central
Author	Nychas, Emmanouil Marfil-Sánchez, Andrea Chen, Xiuqiang Mirhakkak, Mohammad Li, Huating Jia, Weiping Xu, Aimin Nielsen, Henrik Bjørn Nieuwdorp, Max Loomba, Rohit Ni, Yueqiong Panagiotou, Gianni
Abstract	Background The pathogenesis of non-alcoholic fatty liver disease (NAFLD) with a global prevalence of 30% is multifactorial and the involvement of gut bacteria has been recently proposed. However, finding robust bacterial signatures of NAFLD has been a great challenge, mainly due to its co-occurrence with other metabolic diseases. Results Here, we collected public metagenomic data and integrated the taxonomy profiles with in silico generated community metabolic outputs, and detailed clinical data, of 1206 Chinese subjects w/wo metabolic diseases, including NAFLD (obese and lean), obesity, T2D, hypertension, and atherosclerosis. We identified highly specific microbiome signatures through building accurate machine learning models (accuracy = 0.845–0.917) for NAFLD with high portability (generalizable) and low prediction rate (specific) when applied to other metabolic diseases, as well as through a community approach involving differential co-abundance ecological networks. Moreover, using these signatures coupled with further mediation analysis and metabolic dependency modeling, we propose synergistic defined microbial consortia associated with NAFLD phenotype in overweight and lean individuals, respectively. Conclusion Our study reveals robust and highly specific NAFLD signatures and offers a more realistic microbiome-therapeutics approach over individual species for this complex disease. Video Abstract
Related Links	https://microbiomejournal.biomedcentral.com/counter/pdf/10.1186/s40168-024-01990-y.pdf
Ending Page	21
Page Count	21
Starting Page	1
File Format	HTM / HTML
ISSN	20492618
DOI	10.1186/s40168-024-01990-y
Journal	Microbiome
Issue Number	1
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2025-01-14
Access Restriction	Open
Subject Keyword	Medical Microbiology Bioinformatics Microbial Ecology Microbiology Microbial Genetics and Genomics Virology NAFLD Gut microbiota Metabolic diseases Machine learning Network analysis Metabolomics Microbial consortia
Content Type	Text
Resource Type	Article
Subject	Microbiology Microbiology (medical)
Journal Impact Factor	13.8/2023
5-Year Journal Impact Factor	17.9/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease

The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population

Gut microbiome transitions across generations in different ethnicities in an urban setting—the HELIUS study

A meta-analysis study of the robustness and universality of gut microbiome-metabolome associations

Identification of robust and generalizable biomarkers for microbiome-based stratification in lifestyle interventions

Statistical modeling of gut microbiota for personalized health status monitoring

Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease

Similar Documents

Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease

Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease

The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population

Gut microbiome transitions across generations in different ethnicities in an urban setting—the HELIUS study

A meta-analysis study of the robustness and universality of gut microbiome-metabolome associations

Identification of robust and generalizable biomarkers for microbiome-based stratification in lifestyle interventions

Statistical modeling of gut microbiota for personalized health status monitoring

Discovery of robust and highly specific microbiome signatures of non-alcoholic fatty liver disease