NDLI: Novel insights into TCR-T cell therapy in solid neoplasms: optimizing adoptive immunotherapy

Content Provider	Springer Nature : BioMed Central
Author	Shao, Weihuan Yao, Yiran Yang, Ludi Li, Xiaoran Ge, Tongxin Zheng, Yue Zhu, Qiuyi Ge, Shengfang Gu, Xiang Jia, Renbing Song, Xin Zhuang, Ai
Abstract	Adoptive immunotherapy in the T cell landscape exhibits efficacy in cancer treatment. Over the past few decades, genetically modified T cells, particularly chimeric antigen receptor T cells, have enabled remarkable strides in the treatment of hematological malignancies. Besides, extensive exploration of multiple antigens for the treatment of solid tumors has led to clinical interest in the potential of T cells expressing the engineered T cell receptor (TCR). TCR-T cells possess the capacity to recognize intracellular antigen families and maintain the intrinsic properties of TCRs in terms of affinity to target epitopes and signal transduction. Recent research has provided critical insight into their capability and therapeutic targets for multiple refractory solid tumors, but also exposes some challenges for durable efficacy. In this review, we describe the screening and identification of available tumor antigens, and the acquisition and optimization of TCRs for TCR-T cell therapy. Furthermore, we summarize the complete flow from laboratory to clinical applications of TCR-T cells. Last, we emerge future prospects for improving therapeutic efficacy in cancer world with combination therapies or TCR-T derived products. In conclusion, this review depicts our current understanding of TCR-T cell therapy in solid neoplasms, and provides new perspectives for expanding its clinical applications and improving therapeutic efficacy.
Related Links	https://ehoonline.biomedcentral.com/counter/pdf/10.1186/s40164-024-00504-8.pdf
Ending Page	34
Page Count	34
Starting Page	1
File Format	HTM / HTML
ISSN	21623619
DOI	10.1186/s40164-024-00504-8
Journal	Experimental Hematology & Oncology
Issue Number	1
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2024-04-03
Access Restriction	Open
Subject Keyword	Hematology Oncology Cancer Research T cell receptor TCR-T cell Immunotherapy Solid tumor Tumor antigen Clinical application
Content Type	Text
Resource Type	Review
Subject	Hematology Oncology Cancer Research
Journal Impact Factor	9.4/2023
5-Year Journal Impact Factor	8.3/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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