NDLI: Current advances and challenges in CAR T-Cell therapy for solid tumors: tumor-associated antigens and the tumor microenvironment

Content Provider	Springer Nature : BioMed Central
Author	Yan, Ting Zhu, Lingfeng Chen, Jin
Abstract	The past decade has witnessed ongoing progress in immune therapy to ameliorate human health. As an emerging technique, chimeric antigen receptor (CAR) T-cell therapy has the advantages of specific killing of cancer cells, a high remission rate of cancer-induced symptoms, rapid tumor eradication, and long-lasting tumor immunity, opening a new window for tumor treatment. However, challenges remain in CAR T-cell therapy for solid tumors due to target diversity, tumor heterogeneity, and the complex microenvironment. In this review, we have outlined the development of the CAR T-cell technique, summarized the current advances in tumor-associated antigens (TAAs), and highlighted the importance of tumor-specific antigens (TSAs) or neoantigens for solid tumors. We also addressed the challenge of the TAA binding domain in CARs to overcome off-tumor toxicity. Moreover, we illustrated the dominant tumor microenvironment (TME)-induced challenges and new strategies based on TME-associated antigens (TMAs) for solid tumor CAR T-cell therapy.
Related Links	https://ehoonline.biomedcentral.com/counter/pdf/10.1186/s40164-023-00373-7.pdf
Ending Page	18
Page Count	18
Starting Page	1
File Format	HTM / HTML
ISSN	21623619
DOI	10.1186/s40164-023-00373-7
Journal	Experimental Hematology & Oncology
Issue Number	1
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2023-01-27
Access Restriction	Open
Subject Keyword	Hematology Oncology Cancer Research CAR T cells Solid tumor TAAs TSAs TMAs
Content Type	Text
Resource Type	Review
Subject	Hematology Oncology Cancer Research
Journal Impact Factor	9.4/2023
5-Year Journal Impact Factor	8.3/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances

Advances in CAR-T-cell therapy in T-cell malignancies

The expansion of targetable biomarkers for CAR T cell therapy

Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

CAR-NK Cell: A New Paradigm in Tumor Immunotherapy

CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment

Current advances and challenges in CAR T-Cell therapy for solid tumors: tumor-associated antigens and the tumor microenvironment

Similar Documents

Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

Optimizing CAR-T cell therapy for solid tumors: current challenges and potential strategies

CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances

Advances in CAR-T-cell therapy in T-cell malignancies

The expansion of targetable biomarkers for CAR T cell therapy

Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

CAR-NK Cell: A New Paradigm in Tumor Immunotherapy

CAR-T cells and BiTEs in solid tumors: challenges and perspectives

Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment

Current advances and challenges in CAR T-Cell therapy for solid tumors: tumor-associated antigens and the tumor microenvironment