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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Geisler, Benjamin P. Zahabi, Lara Lang, Adam Edward Eastwood, Naomi Tennant, Elaine Lukic, Ljiljana Sharon, Elad Chuang, Hai-Hua Kang, Chang-Berm Clayton-Johnson, Knakita Aljaberi, Ahmed Yu, Haining Bui, Chinh Le Mau, Tuan Li, Wen-Cheng Teodorescu, Debbie Hinske, Ludwig Christian Sun, Dennis L. Manian, Farrin A. Dunn, Adam G. |
| Abstract | Background Coronavirus disease 2019 (COVID-19) has no confirmed specific treatments. However, there might be in vitro and early clinical data as well as evidence from severe acute respiratory syndrome and Middle Eastern respiratory syndrome that could inform clinicians and researchers. This systematic review aims to create priorities for future research of drugs repurposed for COVID-19. Methods This systematic review will include in vitro, animal, and clinical studies evaluating the efficacy of a list of 34 specific compounds and 4 groups of drugs identified in a previous scoping review. Studies will be identified both from traditional literature databases and pre-print servers. Outcomes assessed will include time to clinical improvement, time to viral clearance, mortality, length of hospital stay, and proportions transferred to the intensive care unit and intubated, respectively. We will use the GRADE methodology to assess the quality of the evidence. Discussion The challenge posed by COVID-19 requires not just a rapid review of drugs that can be repurposed but also a sustained effort to integrate new evidence into a living systematic review. Trial registration PROSPERO 2020 CRD42020175648 |
| Related Links | https://systematicreviewsjournal.biomedcentral.com/counter/pdf/10.1186/s13643-021-01693-7.pdf |
| Ending Page | 5 |
| Page Count | 5 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20464053 |
| DOI | 10.1186/s13643-021-01693-7 |
| Journal | Systematic Reviews |
| Issue Number | 1 |
| Volume Number | 10 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-05-07 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Biomedicine Statistics for Life Sciences Health Sciences COVID-19 SARS-CoV2 Severe acute respiratory syndrome SARS Middle East respiratory syndrome Coronavirus MERS-CoV Repurposed Repurposing Medicine/Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
| Journal Impact Factor | 6.3/2023 |
| 5-Year Journal Impact Factor | 4.5/2023 |
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