NDLI: Efficacy of vitamin C supplementation as an adjunct in the non-surgical management of periodontitis: a systematic review

Content Provider	Springer Nature : BioMed Central
Author	Fageeh, Hytham N. Fageeh, Hammam I. Prabhu, Ashwin Bhandi, Shilpa Khan, Shahrukh Patil, Shankargouda
Abstract	Background and objective The antioxidant potential of vitamin C is useful in reducing oxidative stress, free radicals, and reactive oxygen species, which may assist in the improved outcomes of periodontal therapy. This systematic review was aimed to evaluate the effectiveness of vitamin C supplementation as an adjunct to non-surgical periodontal therapy, in the management of periodontitis. Data sources PubMed, EMBASE, Cochrane Library, and Web of Science. Study eligibility criteria Randomized controlled trials published between January 1990 and March 2020. Participants People 18 years and older with periodontitis. Study appraisal and synthesis methods The Critical Appraisal Skills Programme (CASP) quality appraisal tool. Results The initial search yielded 441 articles out of which six studies fulfilled the inclusion criteria. Vitamin C supplementation helped improve bleeding indices in gingivitis but did not significantly lead to reduction of probing depths or clinical attachment gain for periodontitis. Conclusion Administration of vitamin C as an adjunct to non-surgical periodontal therapy did not result in clinically significant improvements in pocket probing depths at 3 months in periodontitis patients. With the limited evidence available, no recommendation can be made for supplementation of vitamin C in conjunction with initial periodontal therapy for subjects with periodontitis to improve primary treatment outcome measures.
Related Links	https://systematicreviewsjournal.biomedcentral.com/counter/pdf/10.1186/s13643-020-01554-9.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	20464053
DOI	10.1186/s13643-020-01554-9
Journal	Systematic Reviews
Issue Number	1
Volume Number	10
Language	English
Publisher	BioMed Central
Publisher Date	2021-01-04
Access Restriction	Open
Subject Keyword	Medicine Public Health Biomedicine Statistics for Life Sciences Health Sciences Vitamin C Ascorbic acid Periodontal diseases Gingivitis Periodontitis Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Medicine
Journal Impact Factor	6.3/2023
5-Year Journal Impact Factor	4.5/2023

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