NDLI: Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis

Content Provider	Springer Nature : BioMed Central
Author	Chakiath, Rosemary J. Siddall, Philip J. Kellow, John E. Hush, Julia M. Jones, Mike P. Marcuzzi, Anna Wrigley, Paul J.
Abstract	Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other chronic pain conditions. The presence of widespread hypersensitivity and extra-intestinal pain conditions suggests central nervous dysfunction. While central nervous system dysfunction may involve the spinal cord (central sensitisation) and brain, this review will focus on one brain mechanism, descending pain modulation. Method/design We will conduct a comprehensive search for the articles indexed in the databases Ovid MEDLINE, Ovid Embase, Ovid PsycINFO and Cochrane Central Register of Controlled Trial (CENTRAL) from their inception to August 2015, that report on any aspect of descending pain modulation in irritable bowel syndrome. Two independent reviewers will screen studies for eligibility, assess risk of bias and extract relevant data. Results will be tabulated and, if possible, a meta-analysis will be carried out. Discussion The systematic review outlined in this protocol aims to summarise current knowledge regarding descending pain modulation in IBS. Systematic review registration PROSPERO CRD42015024284
Related Links	https://systematicreviewsjournal.biomedcentral.com/counter/pdf/10.1186/s13643-015-0162-8.pdf
Ending Page	6
Page Count	6
Starting Page	1
File Format	HTM / HTML
ISSN	20464053
DOI	10.1186/s13643-015-0162-8
Journal	Systematic Reviews
Issue Number	1
Volume Number	4
Language	English
Publisher	BioMed Central
Publisher Date	2015-12-10
Access Restriction	Open
Subject Keyword	Medicine Public Health Biomedicine Statistics for Life Sciences Health Sciences Chronic pain Irritable bowel syndrome Central pain mechanisms Central pain modulators Descending pain modulation Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Medicine
Journal Impact Factor	6.3/2023
5-Year Journal Impact Factor	4.5/2023

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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