NDLI: IL-33 ameliorates experimental colitis involving regulation of autophagy of macrophages in mice

Content Provider	Springer Nature : BioMed Central
Author	Wang, Zhongyan Shi, Lifeng Hua, Shuyao Qi, Chang Fang, Min
Abstract	Background Previously, we have demonstrated that IL-33 administration protecting TNBS-induced experimental colitis is associated with facilitation of Th2/Tregs responses in mice. However, whether IL-33 regulates autophagy to ameliorate experimental colitis is unclear. Results IL-33 administration (2 μg/day, intraperitoneal injection), while facilitating Th2/Tregs responses, also enhances the autophagy in mice with TNBS-induced colitis as well as macrophages. In the meantime, we observed that inhibition of the autophagy with 3-methyladenine (3-MA) (24 mg/kg, intraperitoneal injection) in mice exacerbates TNBS-induced experimental colitis. On the contrary, administration of rapamycin (2 mg/kg,intragastric administration), an autophagy-enhancer, alleviates the colitis in mice. In vivo, Immunofluorescence analysis revealed that TNBS combined with IL-33 enhanced the autophagy of macrophages in the inflammatory gut tissue. In vitro, treatment with IL-33 promoted the autophagy of macrophages generated from bone marrow cells in dose-dependant manner. Furthermore, the effect of autophagy-enhancement by IL-33 is TLR4 signaling pathway dependant. Our notion was further confirmed by IL-33-deficient bone marrow-derived macrophages cells. Conclusions IL-33 regulates the autophagy is a new immunoregulatory property on TNBS-induced experimental colitis in mice.
Related Links	https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-019-0271-5.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	20453701
DOI	10.1186/s13578-019-0271-5
Journal	Cell & Bioscience
Issue Number	1
Volume Number	9
Language	English
Publisher	BioMed Central
Publisher Date	2019-01-14
Access Restriction	Open
Subject Keyword	Cell Biology Microbiology Stem Cells Neurobiology Proteomics IL-33 TNBS-induced experimental colitis Autophagy Macrophages TLR4
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology
Journal Impact Factor	6.1/2023
5-Year Journal Impact Factor	7/2023

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