NDLI: Estrogen rescues heart failure through estrogen receptor Beta activation

Content Provider	Springer Nature : BioMed Central
Author	Iorga, Andrea Umar, Soban Ruffenach, Gregoire Aryan, Laila Li, Jingyuan Sharma, Salil Motayagheni, Negar Nadadur, Rangarajan D. Bopassa, Jean C. Eghbali, Mansoureh
Abstract	Background Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen receptors alpha (ERα) and/or beta (ERβ), and both these receptors are present in the heart, we examined the role of ERα and ERβ in the rescue action of E2 against HF. Methods Severe HF was induced in male mice by transverse aortic constriction-induced pressure overload. Once the ejection fraction (EF) reached ~ 35%, mice were treated with selective agonists for ERα (PPT, 850 μg/kg/day), ERβ (DPN, 850 μg/kg/day), or E2 (30 μg/kg/day) together with an ERβ-antagonist (PHTPP, 850 μg/kg/day) for 10 days. Results EF of HF mice was significantly improved to 45.3 ± 2.1% with diarylpropionitrile (DPN) treatment, but not with PPT (31.1 ± 2.3%). E2 failed to rescue HF in the presence of PHTPP, as there was no significant improvement in the EF at the end of the 10-day treatment (32.5 ± 5.2%). The improvement of heart function in HF mice treated with ERβ agonist DPN was also associated with reduced cardiac fibrosis and increased cardiac angiogenesis, while the ERα agonist PPT had no significant effect on either cardiac fibrosis or angiogenesis. Furthermore, DPN improved hemodynamic parameters in HF mice, whereas PPT had no significant effect. Conclusions E2 treatment rescues pre-existing severe HF mainly through ERβ. Rescue of HF by ERβ activation is also associated with stimulation of cardiac angiogenesis, suppression of fibrosis, and restoration of hemodynamic parameters.
Related Links	https://bsd.biomedcentral.com/counter/pdf/10.1186/s13293-018-0206-6.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	20426410
DOI	10.1186/s13293-018-0206-6
Journal	Biology of Sex Differences
Issue Number	1
Volume Number	9
Language	English
Publisher	BioMed Central
Publisher Date	2018-10-30
Access Restriction	Open
Subject Keyword	Human Physiology Endocrinology Estrogen Heart failure Angiogenesis Fibrosis Estrogen receptor Beta Estrogen receptor alpha
Content Type	Text
Resource Type	Article
Subject	Gender Studies Endocrinology
Journal Impact Factor	4.9/2023
5-Year Journal Impact Factor	6/2023

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Estrogen rescues heart failure through estrogen receptor Beta activation