NDLI: Mesenchymal stem cells: a novel therapeutic approach for feline inflammatory bowel disease

Content Provider	Springer Nature : BioMed Central
Author	Xie, Qiyun Gong, Saisai Cao, Jintao Li, Aoyun Kulyar, Md. F. Wang, Bingyun Li, Jiakui
Abstract	Background Inflammatory bowel disease (IBD) poses a significant and growing global health challenge, affecting both humans and domestic cats. Research on feline IBD has not kept pace with its widespread prevalence in human populations. This study aimed to develop a model of feline IBD by incorporating dextran sulfate sodium (DSS) to evaluate the therapeutic potential of MSCs and to elucidate the mechanisms that enhance their action. Methods We conducted a comprehensive clinical assessment, including magnetic resonance imaging (MRI), endoscopy, and histopathological examination. Additionally, alterations in intestinal microbiota were characterized by 16 S rDNA sequencing, and the influence of MSCs on IBD-related gene expression was investigated through transcriptome analysis. Results According to our findings, MSC treatment significantly mitigated DSS-induced clinical manifestations, reduced inflammatory cell infiltration, decreased the production of inflammatory mediators, and promoted mucosal repair. Regarding the intestinal microbiota, MSC intervention effectively corrected the DSS-induced dysbiosis, increasing the presence of beneficial bacteria and suppressing the proliferation of harmful bacteria. Transcriptome analysis revealed the ability of MSCs to modulate various inflammatory and immune-related signaling pathways, including cytokine-cytokine receptor interactions, TLR signaling pathways, and NF-κB pathways. Conclusion The collective findings indicate that MSCs exert multifaceted therapeutic effects on IBD, including the regulation of intestinal microbiota balance, suppression of inflammatory responses, enhancement of intestinal barrier repair, and modulation of immune responses. These insights provide a solid scientific foundation for employing MSCs as an innovative therapeutic strategy for IBD and pave the way for future clinical explorations.
Related Links	https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-024-04038-y.pdf
Ending Page	17
Page Count	17
Starting Page	1
File Format	HTM / HTML
ISSN	17576512
DOI	10.1186/s13287-024-04038-y
Journal	Stem Cell Research & Therapy
Issue Number	1
Volume Number	15
Language	English
Publisher	BioMed Central
Publisher Date	2024-11-09
Access Restriction	Open
Subject Keyword	Stem Cells Cell Biology Regenerative Medicine Tissue Engineering Biomedical Engineering and Bioengineering Inflammatory bowel disease Cat model Mesenchymal stem cells (MSCs) Intestinal microbiota Regenerative Medicine/Tissue Engineering
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry, Genetics and Molecular Biology Molecular Medicine
Journal Impact Factor	7.1/2023
5-Year Journal Impact Factor	7.9/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6

The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis

How to enhance MSCs therapeutic properties? An insight on potentiation methods

Manipulated mesenchymal stem cell therapy in the treatment of Parkinson’s disease

Improved therapeutic consistency and efficacy of CD317+ MSCs through stabilizing TSG6 by PTX3

Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens

Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

Mesenchymal stem cells and acellular products attenuate murine induced colitis

A novel serum-free medium for the expansion of human mesenchymal stem cells

Mesenchymal stem cells: a novel therapeutic approach for feline inflammatory bowel disease

Similar Documents

A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6

The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis

How to enhance MSCs therapeutic properties? An insight on potentiation methods

Manipulated mesenchymal stem cell therapy in the treatment of Parkinson’s disease

Improved therapeutic consistency and efficacy of CD317+ MSCs through stabilizing TSG6 by PTX3

Intercellular adhesion molecule-1 enhances the therapeutic effects of MSCs in a dextran sulfate sodium-induced colitis models by promoting MSCs homing to murine colons and spleens

Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells

Mesenchymal stem cells and acellular products attenuate murine induced colitis

A novel serum-free medium for the expansion of human mesenchymal stem cells

Mesenchymal stem cells: a novel therapeutic approach for feline inflammatory bowel disease