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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Liang, Chih-Sung Su, Kuan-Pin Tsai, Chia-Lin Lee, Jiunn-Tay Chu, Che-Sheng Yeh, Ta-Chuan Su, Ming-Wei Lin, Guan-Yu Lin, Yu-Kai Chu, Hsuan-Te Tsai, Chia-Kuang Yang, Fu-Chi |
| Abstract | Background The neuroprotective role of interleukin (IL)-33 is supported by numerous preclinical studies, but it remains uninvestigated in clinical studies of Alzheimer’s disease (AD). We aimed to examine the association between human blood levels of IL-33 and cognitive preservation in amnestic mild cognitive impairment (aMCI) and AD. Methods A total of 100 participants (26 controls, 35 aMCI patients, and 39 AD patients) completed two Mini-Mental State Examinations (MMSEs) over a 1-year interval. In all 100 participants at the second MMSE, we examined the plasma levels of IL-33, IL-β, IL-1 receptor agonist (IL-1RA), beta amyloid (Aβ), and tau and apolipoprotein E (ApoE) genotyping; we also performed Hopkins Verbal Learning Test, Trail Making Test, forward and backward digit span, and Clinical Dementia Rating. Results IL-33 expression showed a positive trend among controls (1/26 = 3.8%), aMCI (9/35 = 25.7%), and AD (17/39 = 43.6%) (trend analysis: P < 0.001). Patients expressing IL-33 preserved their cognitive function compared with IL-33 non-expressing patients (1-year ΔMMSE, 0.16 ± 1.6 vs − 1.5 ± 2.6; P = 0.006). The cognitive preservation was not associated with the lower levels of Aβ, tau, and ApoE ε4, while higher levels of ApoE ε4 and phosphorylated tau were indeed associated with cognitive decline. The aMCI patients with AD conversion during study period had higher proportion of IL-33(−) than non-AD converters (90.9% vs 53.3%, P = 0.04). Conclusions IL-33 or its associated signaling pathways may represent a new treatment paradigm for aMCI and AD. |
| Related Links | https://alzres.biomedcentral.com/counter/pdf/10.1186/s13195-020-00652-z.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17589193 |
| DOI | 10.1186/s13195-020-00652-z |
| Journal | Alzheimer's Research & Therapy |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-07-16 |
| Access Restriction | Open |
| Subject Keyword | Neurosciences Neurology Geriatrics Gerontology Geriatric Psychiatry Cytokine Interleukin-33 Alzheimer’s disease Mild cognitive disorder Cognitive decline Geriatrics/Gerontology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Neurology (clinical) Cognitive Neuroscience |
| Journal Impact Factor | 8/2023 |
| 5-Year Journal Impact Factor | 8.3/2023 |
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