| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Banday, Shahid Farooq, Zeenat Ganai, Shabir Ahmad Altaf, Mohammad |
| Abstract | Therapeutic intervention of proteins participating in chromatin-mediated signaling with small-molecules is a novel option to reprogram expression networks for restraining disease states. Protein methyltransferases form the prominent family of such proteins regulating gene expression via epigenetic mechanisms thereby representing novel targets for pharmacological intervention. Disruptor of telomeric silencing, hDot1L is the only non-SET domain containing histone methyltransferase that methylates histone H3 at lysine 79. H3K79 methylation mediated by hDot1L plays a crucial role in mixed lineage leukemia (MLL) pathosis. MLL fusion protein mediated mistargeting of DOT1L to aberrant gene locations results in ectopic H3K79 methylation culminating in aberrant expression of leukemogenic genes like HOXA9 and MEIS1. hDOT1L has thus been proposed as a potential target for therapeutic intervention in MLL. This review presents the general overview of hDOT1L and its functional role in distinct biological processes. Furthermore, we discuss various therapeutic strategies against hDOT1L as a promising drug target to vanquish therapeutically challenging MLL. |
| Related Links | https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-020-00860-2.pdf |
| Ending Page | 9 |
| Page Count | 9 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 18687083 |
| DOI | 10.1186/s13148-020-00860-2 |
| Journal | Clinical Epigenetics |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-05-25 |
| Access Restriction | Open |
| Subject Keyword | Human Genetics Gene Function Chromatin Histone methyltransferases Histone methylation DNA repair Mixed lineage leukemia Gene expression |
| Content Type | Text |
| Resource Type | Review |
| Subject | Molecular Biology Genetics (clinical) Developmental Biology Genetics |
| Journal Impact Factor | 4.8/2023 |
| 5-Year Journal Impact Factor | 5.8/2023 |
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