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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Lundt, Andreas Henseler, Christina Wormuth, Carola Soos, Julien Seidel, Robin Müller, Ralf Arshaad, Muhammad Imran Broich, Karl Hescheler, Jürgen Sachinidis, Agapios Ehninger, Dan Papazoglou, Anna Weiergräber, Marco |
| Abstract | Objectives Voltage-gated Ca2+ channels (VGCCs) are of central relevance in regulating Ca2+ influx into living cells. The low-voltage activated (LVA) Cav3 T-type Ca2+ channels are widely distributed throughout the brain including the peripheral auditory system and ascending auditory tract. Their exact role in auditory information processing is still not fully understood. Within the LVA subgroup, Cav3.2 T-type Ca2+ channels seem to be of special importance as qPCR revealed a steady increase in Cav3.2 transcript levels over age, e.g. in the cochlea and spiral ganglion neurons (SGN). Furthermore, pharmacological studies suggested an association between Cav3.2 expression and both age-related and noise-induced hearing loss. Given the potential functional relevance of Cav3.2 VGGCs in sensorineural hearing loss, we recorded gender specific auditory evoked brainstem responses (ABRs) upon both click and tone burst presentation. Here we present auditory brainstem response (ABR) data from Cav3.2+/+, Cav3.2+/− and Cav3.2−/− mice from both genders which are of value for researchers who want to evaluate how Cav3.2 loss affects basic auditory parameters, e.g. click and tone burst based hearing thresholds, amplitude growth function and peak latencies. Data description Information presented here includes ABR data from age-matched female and male Cav3.2+/+, Cav3.2+/− and Cav3.2−/− mice and technical aspects of the auditory recording protocol. Data were recorded using a commercially available ABR setup from Tucker Davis Technologies Inc. (TDT). Raw data files (arf.-file format) were exported as txt.-files with free access for analysis. |
| Related Links | https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/s13104-019-4169-4.pdf |
| Ending Page | 3 |
| Page Count | 3 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17560500 |
| DOI | 10.1186/s13104-019-4169-4 |
| Journal | BMC Research Notes |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-03-20 |
| Access Restriction | Open |
| Subject Keyword | Biomedicine Medicine Public Health Life Sciences Amplitude Auditory brainstem responses Calcium channel Cav3.2 Click Monaural Sound pressure level Threshold Tone burst Transgenic mice T-Type Medicine/Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology Medicine |
| Journal Impact Factor | 1.6/2023 |
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