NDLI: Effects of 12-weeks resistance training and vitamin E supplementation on aminotransferases, CTRP-2, and CTRP-9 levels in males with nonalcoholic fatty liver disease: a double-blind, randomized trial

Content Provider	Springer Nature : BioMed Central
Author	Varmazyar, Irfan Monazzami, Amir Abbas Moradi, Mozhgan McAinch, Andrew J
Abstract	Background Nonalcoholic fatty liver disease (NAFLD) involves excessive liver fat accumulation and is closely linked to oxidative stress, which contributes to liver inflammation and damage. This study aimed to evaluate how interventions such as resistance training (RT) and vitamin E supplementation (VES) can modulate markers of NAFLD and key proteins regulating glucose and lipid metabolism, such as C1Q/TNF-related proteins (CTRPs). Methods Forty participants with NAFLD (mean age: 32.4 ± 8.2 years) were randomly assigned to one of four groups for 12 weeks: placebo (PLB), VES, PLB + RT, and VES + RT. VES was administered at 800 IU/day in a double-blind manner. The RT regimen included eight exercises at 60–80% of one-repetition maximum (1RM), with three sets of 8–12 repetitions, performed three times per week. Pre- and post-intervention assessments included body composition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lipid profile, glycemic control, CTRP-2, CTRP-9, and 1RM evaluations. Results Following the interventions, there was a significant improvement in body composition, lipid profile, glycemic control, and 1RM indices in the exercise groups compared to non-exercise groups (p < 0.05). AST and ALT levels decreased in all groups (p < 0.05) compared to the PLB group. There was also a significant difference between the VES + RT group and both the VES and PLB + RT groups (p < 0.05). CTRP-2 and CTRP-9 levels decreased in the exercise groups compared to non-exercise groups (p < 0.05), and their changes showed a marked correlation with body composition, lipid profile, and glycemic control indices (p < 0.05). Conclusions This study highlights the benefits of RT on various health parameters among NAFLD patients. While adding VES to RT resulted in greater decreases in aminotransferases, it did not provide further improvements in other variables. Additionally, enhancements in body composition, lipid profile, and glycemic control indices were possibly associated with decreased levels of CTRPs. Trial registration Registered retrospectively in the Iranian Registry of Clinical Trials (IRCT20220601055056N1) on December 21, 2023. Access at https://irct.behdasht.gov.ir/trial/69231 .
Related Links	https://bmcsportsscimedrehabil.biomedcentral.com/counter/pdf/10.1186/s13102-024-00972-9.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
ISSN	20521847
DOI	10.1186/s13102-024-00972-9
Journal	BMC Sports Science, Medicine and Rehabilitation
Issue Number	1
Volume Number	16
Language	English
Publisher	BioMed Central
Publisher Date	2024-09-04
Access Restriction	Open
Subject Keyword	BMC Sports Science Medicine and Rehabilitation Sports Medicine Orthopedics Rehabilitation Medicine Resistance training Vitamin E NAFLD CTRPs Insulin Lipid profile
Content Type	Text
Resource Type	Article
Subject	Physical Therapy, Sports Therapy and Rehabilitation Rehabilitation Orthopedics and Sports Medicine
Journal Impact Factor	2.1/2023
5-Year Journal Impact Factor	2.3/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Vitamin C and E supplementation and high intensity interval training induced changes in lipid profile and haematological variables of young males.

Can supplementation with vitamin C and E alter physiological adaptations to strength training?

Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease

Effects of resistance training and turmeric supplementation on reactive species marker stress in diabetic rats

Exercise as ‘precision medicine’ for insulin resistance and its progression to type 2 diabetes: a research review

The effects of two weeks high-intensity interval training on fasting glucose, glucose tolerance and insulin resistance in adolescent boys: a pilot study

Aerobic training and vitamin D supplementation effects on diabetes-related parameters in a rat model of type 2 diabetes

The relationship between the gut microbiome and resistance training: a rapid review

Eccentric-only versus concentric-only resistance training effects on biochemical and physiological parameters in patients with type 2 diabetes

Effects of 12-weeks resistance training and vitamin E supplementation on aminotransferases, CTRP-2, and CTRP-9 levels in males with nonalcoholic fatty liver disease: a double-blind, randomized trial

Similar Documents

Vitamin C and E supplementation and high intensity interval training induced changes in lipid profile and haematological variables of young males.

Can supplementation with vitamin C and E alter physiological adaptations to strength training?

Micronutrient Antioxidants and Nonalcoholic Fatty Liver Disease

Effects of resistance training and turmeric supplementation on reactive species marker stress in diabetic rats

Exercise as ‘precision medicine’ for insulin resistance and its progression to type 2 diabetes: a research review

The effects of two weeks high-intensity interval training on fasting glucose, glucose tolerance and insulin resistance in adolescent boys: a pilot study

Aerobic training and vitamin D supplementation effects on diabetes-related parameters in a rat model of type 2 diabetes

The relationship between the gut microbiome and resistance training: a rapid review

Eccentric-only versus concentric-only resistance training effects on biochemical and physiological parameters in patients with type 2 diabetes

Effects of 12-weeks resistance training and vitamin E supplementation on aminotransferases, CTRP-2, and CTRP-9 levels in males with nonalcoholic fatty liver disease: a double-blind, randomized trial