NDLI: The mediating role of inflammation in the association between pregnancy loss history and gestational diabetes mellitus

Content Provider	Springer Nature : BioMed Central
Author	Li, Qiong Wang, Haixia Sun, Lijun Wang, Peng Yin, Wanjun Ma, Shuangshuang Tao, Ruixue Ge, Jinfang Zhu, Peng
Abstract	Background To assess the association of pregnancy loss history with an elevated risk of Gestational diabetes mellitus (GDM) and to investigate whether this association was mediated by high-sensitivity C-reactive protein (hs-CRP). Methods We prospectively collected venous blood and pregnancy loss history information from 4873 pregnant women at 16–23 weeks of gestation from March 2018 to April 2022. Hs-CRP concentrations were measured from collected blood samples. A 75 g fasting glucose test was performed at 24 to 28 weeks of gestation for the diagnosis of GDM, with data obtained from medical records. Multivariate linear or logistic regression models and mediation analysis were used to examine the relationships between pregnancy loss history, hs-CRP, and GDM. Results A multivariable-adjusted logistic regression analysis revealed that compared with pregnant women with no induced abortion history, subjects with 1 and ≥ 2 induced abortions had a higher risk for GDM (RR = 1.47, 95% CI = 1.19–1.81; RR = 1.63, 95% CI = 1.28–2.09). Additionally, the mediation analysis indicated this association was mediated by an increased hs-CRP level with a 20.4% of indirect effect ratio. However, no significant association between a history of miscarriage and the prevalence of GDM was observed. Conclusions A history of induced abortion was significantly associated with an increased risk of GDM, and this association occurred in a dose-response effect. Hs-CRP may be accounted for a mediation effect in the pathways linking induced abortion history with GDM.
Related Links	https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/s13098-023-01106-w.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
ISSN	17585996
DOI	10.1186/s13098-023-01106-w
Journal	Diabetology & Metabolic Syndrome
Issue Number	1
Volume Number	15
Language	English
Publisher	BioMed Central
Publisher Date	2023-06-21
Access Restriction	Open
Subject Keyword	Diabetes Metabolic Diseases Endocrinology Pregnancy loss Induced abortion Miscarriage Gestational diabetes mellitus Inflammation
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine
Journal Impact Factor	3.4/2023
5-Year Journal Impact Factor	4.1/2023

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