NDLI: Dietary supplementation of inulin alleviates metabolism disorders in gestational diabetes mellitus mice via RENT/AKT/IRS/GLUT4 pathway

Content Provider	Springer Nature : BioMed Central
Author	Miao, Miao Dai, Yongmei Rui, Can Fan, Yuru Wang, Xinyan Fan, Chong Mu, Juan Hou, Wenwen Dong, Zhiyong Li, Ping Sun, Guiju Zeng, Xin
Abstract	Background Gestational diabetes mellitus (GDM) has significant short and long-term health consequences for both the mother and child. There is limited but suggestive evidence that inulin could improve glucose tolerance during pregnancy. This study assessed the effect of inulin on glucose homeostasis and elucidated the molecular mechanisms underlying the inulin-induced antidiabetic effects during pregnancy. Method Female C57BL/6 mice were randomized to receive either no treatment, high-dose inulin and low-dose inulin for 7 weeks with measurement of biochemical profiles. A real-time2 (RT2) profiler polymerase chain reaction (PCR) array involved in glycolipid metabolism was measured. Results Inulin treatment facilitated glucose homeostasis in a dose-dependent manner by decreasing fasting blood glucose, advanced glycation end products and total cholesterol, and improving glucose tolerance. Suppressing resistin (RETN) expression was observed in the inulin treatment group and the expression was significantly correlated with fasting blood glucose levels. The ratios of p-IRS to IRS and p-Akt to Akt in liver tissue and the ratio of p-Akt to Akt in adipose tissue as well as the expression level of GLUT4 increased significantly after inulin treatment. Conclusions Our findings indicated improvement of glucose and lipid metabolism by inulin was to activate glucose transport through the translocation of GLUT4 which was mediated by insulin signaling pathway repairment due to decreased expression of RETN and enhanced phosphorylation of IRS and Akt in GDM mice.
Related Links	https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/s13098-021-00768-8.pdf
Ending Page	14
Page Count	14
Starting Page	1
File Format	HTM / HTML
ISSN	17585996
DOI	10.1186/s13098-021-00768-8
Journal	Diabetology & Metabolic Syndrome
Issue Number	1
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2021-12-24
Access Restriction	Open
Subject Keyword	Diabetes Metabolic Diseases Endocrinology Gestational diabetes Fasting blood glucose Inulin Glycolysis/gluconeogenesis pathway RETN
Content Type	Text
Resource Type	Article
Subject	Endocrinology, Diabetes and Metabolism Internal Medicine
Journal Impact Factor	3.4/2023
5-Year Journal Impact Factor	4.1/2023

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