| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Herold, Zoltan Herold, Magdolna Rosta, Klara Doleschall, Marton Somogyi, Aniko |
| Abstract | Background Chromogranin B (CgB) plays an important role in the physiological insulin secretion of pancreatic beta cells. Serum CgB levels were investigated in type 1 and type 2 diabetes patients in a cross-sectional study. Methods An observational cross-sectional study was performed with the inclusion of 94 control subjects, 100 type 1 and 100 type 2 diabetes patients, at the Metabolic Outpatient Clinic of the Department of Internal Medicine and Hematology, Semmelweis University. Serum CgB levels were measured with enzyme-linked immunosorbent assay. Results Serum CgB level was lower in type 1 diabetes patients than in matched control subjects (p = 0.0241), while they were equal in type 2 diabetes patients and controls (p = 0.1698). The subgroup of type 2 diabetes patients who received intensive conservative insulin treatment had significantly lower CgB levels compared to those with other regimens of antidiabetic therapies (p = 0.0283). Conclusion The lower serum CgB levels in the patients with type 1 diabetes and the type 2 diabetes patients with progressed disease stage suggested that the CgB production might be decreased due to the beta cell destruction and depletion. |
| Related Links | https://dmsjournal.biomedcentral.com/counter/pdf/10.1186/s13098-020-00569-5.pdf |
| Ending Page | 5 |
| Page Count | 5 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17585996 |
| DOI | 10.1186/s13098-020-00569-5 |
| Journal | Diabetology & Metabolic Syndrome |
| Issue Number | 1 |
| Volume Number | 12 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-07-14 |
| Access Restriction | Open |
| Subject Keyword | Diabetes Metabolic Diseases Endocrinology Chromogranin A Chromogranin B Diabetes mellitus Type 1 Diabetes mellitus Type 2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism Internal Medicine |
| Journal Impact Factor | 3.4/2023 |
| 5-Year Journal Impact Factor | 4.1/2023 |
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