NDLI: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

Content Provider	Springer Nature : BioMed Central
Author	Rice, Lisa M. Mantero, Julio C. Stratton, Eric A. Warburton, Rod Roberts, Kari Hill, Nicholas Simms, Robert W. Domsic, Robyn Farber, Harrison W. Layfatis, Robert
Abstract	Background Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is one of the leading causes of death in SSc. Identification of a serum-based proteomic diagnostic biomarker for SSc-PAH would allow for rapid non-invasive screening and could positively impact patient survival. Identification and validation of novel proteins could potentially facilitate the identification of SSc-PAH, and might also point to important protein mediators in pathogenesis. Methods Thirteen treatment-naïve SSc-PAH patients had serum collected at time of diagnosis and were used as the discovery cohort for the protein-expression biomarker. Two proteins, Midkine and Follistatin-like 3 (FSTL3) were then validated by enzyme-linked immunosorbent assays. Midkine and FSTL3 were tested in combination to identify SSc-PAH and were validated in two independent cohorts of SSc-PAH (n = 23, n = 11). Results Eighty-two proteins were found to be differentially regulated in SSc-PAH sera. Two proteins (Midkine and FSTL3) were also shown to be elevated in publicly available data and their expression was evaluated in independent cohorts. In the validation cohorts, the combination of Midkine and FSTL3 had an area under the receiver operating characteristic curve (AUC) of 0.85 and 0.92 with respective corresponding measures of sensitivity of 76% and 91%, and specificity measures of 76% and 80%. Conclusions These findings indicate that there is a clear delineation between overall protein expression in sera from SSc patients and those with SSc-PAH. The combination of Midkine and FSTL3 can serve as an SSc-PAH biomarker and are potential drug targets for this rare disease population.
Related Links	https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/s13075-018-1679-8.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
ISSN	14786362
DOI	10.1186/s13075-018-1679-8
Journal	Arthritis Research & Therapy
Issue Number	1
Volume Number	20
Language	English
Publisher	BioMed Central
Publisher Date	2018-08-16
Access Restriction	Open
Subject Keyword	Rheumatology Orthopedics Classification Proteomic Scleroderma Biomarkers Pulmonary arterial hypertension
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology Rheumatology
Journal Impact Factor	4.4/2023
5-Year Journal Impact Factor	4.9/2023

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Correction: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

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Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

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Correction: Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

Sex disparities in systemic sclerosis-associated pulmonary arterial hypertension: a cohort study

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