NDLI: Association of area- and volumetric-mammographic density and breast cancer risk in women of Asian descent: a case control study

Content Provider	Springer Nature : BioMed Central
Author	Mariapun, Shivaani Ho, Weang-Kee Eriksson, Mikael Mohd Taib, Nur Aishah Yip, Cheng-Har Rahmat, Kartini Hall, Per Teo, Soo-Hwang
Abstract	Background Mammographic density (MD) has been shown to be a strong and independent risk factor for breast cancer in women of European and Asian descent. However, the majority of Asian studies to date have used BI-RADS as the scoring method and none have evaluated area and volumetric densities in the same cohort of women. This study aims to compare the association of MD measured by two automated methods with the risk of breast cancer in Asian women, and to investigate if the association is different for premenopausal and postmenopausal women. Methods In this case–control study of 531 cases and 2297 controls, we evaluated the association of area-based MD measures and volumetric-based MD measures with breast cancer risk in Asian women using conditional logistic regression analysis, adjusting for relevant confounders. The corresponding association by menopausal status were assessed using unconditional logistic regression. Results We found that both area and volume-based MD measures were associated with breast cancer risk. Strongest associations were observed for percent densities (OR (95% CI) was 2.06 (1.42–2.99) for percent dense area and 2.21 (1.44–3.39) for percent dense volume, comparing women in highest density quartile with those in the lowest quartile). The corresponding associations were significant in postmenopausal but not premenopausal women (premenopausal versus postmenopausal were 1.59 (0.95–2.67) and 1.89 (1.22–2.96) for percent dense area and 1.24 (0.70–2.22) and 1.96 (1.19–3.27) for percent dense volume). However, the odds ratios were not statistically different by menopausal status [p difference = 0.782 for percent dense area and 0.486 for percent dense volume]. Conclusions This study confirms the associations of mammographic density measured by both area and volumetric methods and breast cancer risk in Asian women. Stronger associations were observed for percent dense area and percent dense volume, and strongest effects were seen in postmenopausal individuals.
Related Links	https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/s13058-024-01829-2.pdf
Ending Page	15
Page Count	15
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13058-024-01829-2
Journal	Breast Cancer Research
Issue Number	1
Volume Number	26
Language	English
Publisher	BioMed Central
Publisher Date	2024-05-15
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Surgical Oncology Mammographic density Asian Breast cancer
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology
Journal Impact Factor	6.1/2023
5-Year Journal Impact Factor	7.1/2023

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