NDLI: Association between menopausal hormone therapy, mammographic density and breast cancer risk: results from the E3N cohort study

Content Provider	Springer Nature : BioMed Central
Author	Fornili, M. Perduca, V. Fournier, A. Jérolon, A. Boutron-Ruault, M. C. Maskarinec, G. Severi, G. Baglietto, L.
Abstract	Background Menopausal hormone therapy (MHT) is a risk factor for breast cancer (BC). Evidence suggests that its effect on BC risk could be partly mediated by mammographic density. The aim of this study was to investigate the relationship between MHT, mammographic density and BC risk using data from a prospective study. Methods We used data from a case-control study nested within the French cohort E3N including 453 cases and 453 matched controls. Measures of mammographic density, history of MHT use during follow-up and information on potential confounders were available for all women. The association between MHT and mammographic density was evaluated by linear regression models. We applied mediation modelling techniques to estimate, under the hypothesis of a causal model, the proportion of the effect of MHT on BC risk mediated by percent mammographic density (PMD) for BC overall and by hormone receptor status. Results Among MHT users, 4.2% used exclusively oestrogen alone compared with 68.3% who used exclusively oestrogens plus progestogens. Mammographic density was higher in current users (for a 60-year-old woman, mean PMD 33%; 95% CI 31 to 35%) than in past (29%; 27 to 31%) and never users (24%; 22 to 26%). No statistically significant association was observed between duration of MHT and mammographic density. In past MHT users, mammographic density was negatively associated with time since last use; values similar to those of never users were observed in women who had stopped MHT at least 8 years earlier. The odds ratio of BC for current versus never MHT users, adjusted for age, year of birth, menopausal status at baseline and BMI, was 1.67 (95% CI, 1.04 to 2.68). The proportion of effect mediated by PMD was 34% for any BC and became 48% when the correlation between BMI and PMD was accounted for. These effects were limited to hormone receptor-positive BC. Conclusions Our results suggest that, under a causal model, nearly half of the effect of MHT on hormone receptor-positive BC risk is mediated by mammographic density, which appears to be modified by MHT for up to 8 years after MHT termination.
Related Links	https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/s13058-021-01425-8.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13058-021-01425-8
Journal	Breast Cancer Research
Issue Number	1
Volume Number	23
Language	English
Publisher	BioMed Central
Publisher Date	2021-04-17
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Surgical Oncology Mammographic density Menopausal hormone therapy Menopause Breast cancer risk Mediation analysis
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology
Journal Impact Factor	6.1/2023
5-Year Journal Impact Factor	7.1/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

The association of mammographic density with ductal carcinoma in situof the breast: the Multiethnic Cohort

Erratum to: Risk of breast cancer after stopping menopausal hormone therapy in the E3N cohort

Longitudinal history of mammographic breast density and breast cancer risk by familial risk, menopausal status, and initial mammographic density level in a high risk cohort: a nested case–control study

Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study

Use of postmenopausal hormone therapies and risk of histology- and hormone receptor-defined breast cancer: results from a 15-year prospective analysis of NIH-AARP cohort

Do breast cancer risk factors modify the association between hormone therapy and mammographic breast density? (United States)

Mammographic density and breast cancer risk: a mediation analysis

Association between menopausal hormone therapy, mammographic density and breast cancer risk: results from the E3N cohort study

Similar Documents

Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

The association of mammographic density with ductal carcinoma in situof the breast: the Multiethnic Cohort

Erratum to: Risk of breast cancer after stopping menopausal hormone therapy in the E3N cohort

Longitudinal history of mammographic breast density and breast cancer risk by familial risk, menopausal status, and initial mammographic density level in a high risk cohort: a nested case–control study

Hormone metabolism pathway genes and mammographic density change after quitting estrogen and progestin combined hormone therapy in the California Teachers Study

Use of postmenopausal hormone therapies and risk of histology- and hormone receptor-defined breast cancer: results from a 15-year prospective analysis of NIH-AARP cohort

Do breast cancer risk factors modify the association between hormone therapy and mammographic breast density? (United States)

Mammographic density and breast cancer risk: a mediation analysis

Association between menopausal hormone therapy, mammographic density and breast cancer risk: results from the E3N cohort study