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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Lee, Chel Hee Banoei, Mohammad M. Ansari, Mariam Cheng, Matthew P. Lamontagne, Francois Griesdale, Donald Lasry, David E. Demir, Koray Dhingra, Vinay Tran, Karen C. Lee, Terry Burns, Kevin Sweet, David Marshall, John Slutsky, Arthur Murthy, Srinivas Singer, Joel Patrick, David M. Lee, Todd C. Boyd, John H. Walley, Keith R. Fowler, Robert Haljan, Greg Vinh, Donald C. Mcgeer, Alison Maslove, David Mann, Puneet Donohoe, Kathryn Hernandez, Geraldine Rocheleau, Genevieve Trahtemberg, Uriel Kumar, Anand Lou, Ma dos Santos, Claudia Baker, Andrew Russell, James A. Winston, Brent W. |
| Abstract | Rationale Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improve our understanding of ARDS, including its molecular mechanisms, individualized treatment options, and potential interventions to reduce inflammation and promote lung repair. Objective To map and compare metabolic phenotypes of different infectious causes of ARDS to better understand the metabolic pathways involved in the underlying pathogenesis. Methods We analyzed metabolic phenotypes of 3 ARDS cohorts caused by COVID-19, H1N1 influenza, and bacterial pneumonia compared to non-ARDS COVID-19-infected patients and ICU-ventilated controls. Targeted metabolomics was performed on plasma samples from a total of 150 patients using quantitative LC–MS/MS and DI-MS/MS analytical platforms. Results Distinct metabolic phenotypes were detected between different infectious causes of ARDS. There were metabolomics differences between ARDSs associated with COVID-19 and H1N1, which include metabolic pathways involving taurine and hypotaurine, pyruvate, TCA cycle metabolites, lysine, and glycerophospholipids. ARDSs associated with bacterial pneumonia and COVID-19 differed in the metabolism of D-glutamine and D-glutamate, arginine, proline, histidine, and pyruvate. The metabolic profile of COVID-19 ARDS (C19/A) patients admitted to the ICU differed from COVID-19 pneumonia (C19/P) patients who were not admitted to the ICU in metabolisms of phenylalanine, tryptophan, lysine, and tyrosine. Metabolomics analysis revealed significant differences between C19/A, H1N1/A, and PNA/A vs ICU-ventilated controls, reflecting potentially different disease mechanisms. Conclusion Different metabolic phenotypes characterize ARDS associated with different viral and bacterial infections. |
| Related Links | https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-024-04843-0.pdf |
| Ending Page | 16 |
| Page Count | 16 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 13648535 |
| DOI | 10.1186/s13054-024-04843-0 |
| Journal | Critical Care |
| Issue Number | 1 |
| Volume Number | 28 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-02-27 |
| Access Restriction | Open |
| Subject Keyword | Intensive Critical Care Medicine Emergency Medicine Acute respiratory distress syndrome SARS-CoV-2 H1N1 Pneumonia Metabolomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine |
| Journal Impact Factor | 8.8/2023 |
| 5-Year Journal Impact Factor | 10.4/2023 |
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