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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Jiang, Chi-yi Xu, Xiao Jian, Bing-lin Zhang, Xue Yue, Zhi-xia Guo, Wei Ma, Xiao-li |
| Abstract | Background Neuroblastoma (NB) is the most common extracranial solid tumor in children. It is known for high heterogeneity and concealed onset. In recent years, the mechanism of its occurrence and development has been gradually revealed. The purpose of this study is to summarize the clinical characteristics of children with NB and abnormal chromosome 10, and to investigate the relationship between the number and structure of chromosome 10 abnormalities and NB prognosis. Methods Chromosome G-banding was used at the time of diagnosis to evaluate the genetics of chromosomes in patients with NB and track their clinical characteristics and prognosis. All participants were diagnosed with NB in the Medical Oncology Department of the Beijing Children’s Hospital from May 2015 to December 2018 and were followed up with for at least 1 year. Results Of all 150 patients with bone marrow metastases, 42 were clearly diagnosed with chromosomal abnormalities. Thirteen patients showed abnormalities in chromosome 10, and chromosome 10 was the most commonly missing chromosome. These 13 patients had higher LDH and lower OS and EFS than children with chromosomal abnormalities who did not have an abnormality in chromosome 10. Eight patients had both MYCN amplification and 1p36 deletion. Two patients had optic nerve damage and no vision, and one patient had left supraorbital metastases 5 months after treatment. Conclusions The results indicated that chromosome 10 might be a new prognostic marker for NB. MYCN amplification and 1p36 deletion may be related to chromosome 10 abnormalities in NB. Additionally, NB patients with abnormal chromosome 10 were prone to orbital metastases. |
| Related Links | https://ijponline.biomedcentral.com/counter/pdf/10.1186/s13052-021-01085-6.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 18247288 |
| DOI | 10.1186/s13052-021-01085-6 |
| Journal | Italian Journal of Pediatrics |
| Issue Number | 1 |
| Volume Number | 47 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-06-09 |
| Access Restriction | Open |
| Subject Keyword | Pediatrics Maternal and Child Health Chromosome 10 Neuroblastoma Cancer survival Chromosome G-banding |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health |
| Journal Impact Factor | 3.2/2023 |
| 5-Year Journal Impact Factor | 3.2/2023 |
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