NDLI: Efficacy of supraspinatus tendon repair using mesenchymal stem cells along with a collagen I scaffold

Content Provider	Springer Nature : BioMed Central
Author	Tornero-Esteban, Pilar Hoyas, José Antonio Villafuertes, Esther Rodríguez-Bobada, Cruz López-Gordillo, Yamila Rojo, Francisco J. Guinea, Gustavo V. Paleczny, Anna Lópiz-Morales, Yaiza Rodriguez-Rodriguez, Luis Marco, Fernando Fernández-Gutiérrez, Benjamín
Abstract	Objectives Our main objective was to biologically improve rotator cuff healing in an elderly rat model using mesenchymal stem cells (MSCs) in combination with a collagen membrane and compared against other current techniques. Methods A chronic rotator cuff tear injury model was developed by unilaterally detaching the supraspinatus (SP) tendons of Sprague-Dawley rats. At 1 month postinjury, the tears were repaired using one of the following techniques: (a) classical surgery using sutures (n = 12), (b) type I collagen membranes (n = 15), and (c) type I collagen membranes + 1 × 106 allogeneic MSCs (n = 14). Lesion restoration was evaluated at 1, 2, and 3 months postinjury based on biomechanical criteria. Continuous variables were described using mean and standard deviation (SD). To analyse the effect of the different surgical treatments in the repaired tendons’ biomechanical capabilities (maximum load, stiffness, and deformity), a two-way ANOVA model was used, introducing an interaction between such factor and time (1, 2, and 3 months postinjury). Results With regard to maximum load, we observed an almost significant interaction between treatment and time (F = 2.62, df = 4, p = 0.053). When we analysed how this biomechanical capability changed with time for each treatment, we observed that repair with OrthADAPT and MSCs was associated with a significant increase in maximum load (p = 0.04) between months 1 and 3. On the other hand, when we compared the different treatments among themselves at different time points, we observed that the repair with OrthADAPT and MSCs has associated with a significant higher maximum load, when compared with the use of suture, but only at 3 months (p = 0.014). With regard to stiffness and deformity, no significant interaction was observed (F = 1.68, df = 4, p = 0.18; F = 0.40, df = 4, p = 0.81; respectively). Conclusions The implantation of MSCs along with a collagen I scaffold into surgically created tendon defects is safe and effective. MSCs improved the tendon’s maximum load over time, indicating that MSCs could help facilitate the dynamic process of tendon repair.
Related Links	https://josr-online.biomedcentral.com/counter/pdf/10.1186/s13018-015-0269-6.pdf
Ending Page	7
Page Count	7
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13018-015-0269-6
Journal	Journal of Orthopaedic Surgery and Research
Issue Number	1
Volume Number	10
Language	English
Publisher	BioMed Central
Publisher Date	2015-08-14
Access Restriction	Open
Subject Keyword	Orthopedics Surgical Orthopedics Mesenchymal stem cells (MSCs) Animal model Rotator cuff
Content Type	Text
Resource Type	Article
Subject	Surgery Orthopedics and Sports Medicine
Journal Impact Factor	2.8/2023
5-Year Journal Impact Factor	3/2023

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