| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Blethen, K. E. Sprowls, S. A. Arsiwala, T. A. Wolford, C. P. Panchal, D. M. Fladeland, R. A. Glass, M. J. Dykstra, L. P. Kielkowski, B. N. Blackburn, J. R. Andrick, C. J. Lockman, P. R. |
| Abstract | Background Approximately 20% of all cancer patients will develop brain metastases in their lifespan. The standard of care for patients with multiple brain metastases is whole-brain radiation therapy, which disrupts the blood–brain barrier. Previous studies have shown inflammatory mediators play a role in the radiation-mediated increase in permeability. Our goal was to determine if differential permeability post-radiation occurs between immunocompetent and immunocompromised mice. Methods We utilized a commissioned preclinical irradiator to irradiate brains of C57Bl/6J wild-type and athymic nude mice. Acute (3–24 h) effects on blood–brain barrier integrity were evaluated with our in-situ brain perfusion technique and quantitative fluorescent and phosphorescent microscopy. The presence of inflammatory mediators in the brain and serum was determined with a proinflammatory cytokine panel. Results Blood–brain barrier integrity and efflux transporter activity were altered in the immunocompetent mice 12 h following irradiation without similar observations in the immunocompromised mice. We observed increased TNF-α concentrations in the serum of wild-type mice immediately post-radiation and nude mice 12 h post-radiation. The brain concentration of CXCL1 was also increased in both mouse strains at the 12-h time point. Conclusions The immune response plays a role in the magnitude of blood–brain barrier disruption following irradiation in a time- and size-dependent manner. |
| Related Links | https://ro-journal.biomedcentral.com/counter/pdf/10.1186/s13014-023-02215-6.pdf |
| Ending Page | 10 |
| Page Count | 10 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s13014-023-02215-6 |
| Journal | Radiation Oncology |
| Issue Number | 1 |
| Volume Number | 18 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2023-02-03 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Radiotherapy Imaging Radiology Neuroinflammation Immunotherapy Brain metastases Glioblastoma Immune response Vascular permeability Whole brain irradiation Efflux transporter |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Oncology |
| Journal Impact Factor | 3.3/2023 |
| 5-Year Journal Impact Factor | 3.6/2023 |
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