NDLI: Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects

Content Provider	Springer Nature : BioMed Central
Author	Herskind, Carsten Ma, Lin Liu, Qi Zhang, Bo Schneider, Frank Veldwijk, Marlon R. Wenz, Frederik
Abstract	Intraoperative radiotherapy differs from conventional, fractionated radiotherapy in several aspects that may influence its biological effect. The radiation quality influences the relative biologic effectiveness (RBE), and the role of the five R’s of radiotherapy (reassortment, repair, reoxygenation, repopulation, radiosensitivity) is different. Furthermore, putative special biological effects and the small volume receiving a high single dose may be important. The present review focuses on RBE, repair, and repopulation, and gives an overview of the other factors that potentially contribute to the efficacy. The increased RBE should be taken into account for low-energy X-rays while evidence of RBE < 1 for high-energy electrons at higher doses is presented. Various evidence supports a hypothesis that saturation of the primary DNA double-strand break (DSB) repair mechanisms leads to increasing use of an error-prone backup repair system leading to genomic instability that may contribute to inactivate tumour cells at high single doses. Furthermore, the elimination of repopulation of residual tumour cells in the tumour bed implies that some patients are likely to have very few residual tumour cells which may be cured even by low doses to the tumour bed. The highly localised dose distribution of IORT has the potential to inactivate tumour cells while sparing normal tissue by minimising the volume exposed to high doses. Whether special effects of high single doses also contribute to the efficacy will require further experimental and clinical studies.
Related Links	https://ro-journal.biomedcentral.com/counter/pdf/10.1186/s13014-016-0750-3.pdf
Ending Page	14
Page Count	14
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13014-016-0750-3
Journal	Radiation Oncology
Issue Number	1
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2017-01-19
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Radiotherapy Imaging Radiology Dose Distribution Linear Energy Transfer Relative Biologic Effectiveness Accelerate Partial Breast Irradiation Survive Fraction
Content Type	Text
Resource Type	Review
Subject	Radiology, Nuclear Medicine and Imaging Oncology
Journal Impact Factor	3.3/2023
5-Year Journal Impact Factor	3.6/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Toxicity and cosmesis outcomes after single fraction partial breast irradiation in early stage breast cancer

Dose volume histogram analysis of normal structures associated with accelerated partial breast irradiation delivered by high dose rate brachytherapy and comparison with whole breast external beam radiotherapy fields

Accelerated Partial Breast Irradiation (APBI): A review of available techniques

Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity

Five-year oncological outcome after a single fraction of accelerated partial breast irradiation in the elderly

Single fraction of accelerated partial breast irradiation in the elderly: early clinical outcome

The impact of dose calculation algorithms on partial and whole breast radiation treatment plans

Mammographic Findings Associated with Accelerated Partial Breast Irradiation Using Single Fraction Intraoperative Radiotherapy

Calculating dose-averaged linear energy transfer in an analytical treatment planning system for carbon-ion radiotherapy.

Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects

Similar Documents

Toxicity and cosmesis outcomes after single fraction partial breast irradiation in early stage breast cancer

Dose volume histogram analysis of normal structures associated with accelerated partial breast irradiation delivered by high dose rate brachytherapy and comparison with whole breast external beam radiotherapy fields

Accelerated Partial Breast Irradiation (APBI): A review of available techniques

Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity

Five-year oncological outcome after a single fraction of accelerated partial breast irradiation in the elderly

Single fraction of accelerated partial breast irradiation in the elderly: early clinical outcome

The impact of dose calculation algorithms on partial and whole breast radiation treatment plans

Mammographic Findings Associated with Accelerated Partial Breast Irradiation Using Single Fraction Intraoperative Radiotherapy

Calculating dose-averaged linear energy transfer in an analytical treatment planning system for carbon-ion radiotherapy.

Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspects