NDLI: Radiomics based targeted radiotherapy planning (Rad-TRaP): a computational framework for prostate cancer treatment planning with MRI

Content Provider	Springer Nature : BioMed Central
Author	Shiradkar, Rakesh Podder, Tarun K Algohary, Ahmad Viswanath, Satish Ellis, Rodney J. Madabhushi, Anant
Abstract	Background Radiomics or computer – extracted texture features have been shown to achieve superior performance than multiparametric MRI (mpMRI) signal intensities alone in targeting prostate cancer (PCa) lesions. Radiomics along with deformable co-registration tools can be used to develop a framework to generate targeted focal radiotherapy treatment plans. Methods The Rad-TRaP framework comprises three distinct modules. Firstly, a module for radiomics based detection of PCa lesions on mpMRI via a feature enabled machine learning classifier. The second module comprises a multi-modal deformable co-registration scheme to map tissue, organ, and delineated target volumes from MRI onto CT. Finally, the third module involves generation of a radiomics based dose plan on MRI for brachytherapy and on CT for EBRT using the target delineations transferred from the MRI to the CT. Results Rad-TRaP framework was evaluated using a retrospective cohort of 23 patient studies from two different institutions. 11 patients from the first institution were used to train a radiomics classifier, which was used to detect tumor regions in 12 patients from the second institution. The ground truth cancer delineations for training the machine learning classifier were made by an experienced radiation oncologist using mpMRI, knowledge of biopsy location and radiology reports. The detected tumor regions were used to generate treatment plans for brachytherapy using mpMRI, and tumor regions mapped from MRI to CT to generate corresponding treatment plans for EBRT. For each of EBRT and brachytherapy, 3 dose plans were generated - whole gland homogeneous ( P WH $\mathbb {P}^{\text {WH}}$ ) which is the current clinical standard, radiomics based focal ( P RF $\mathbb {P}^{\text {RF}}$ ), and whole gland with a radiomics based focal boost ( P WF $\mathbb {P}^{\text {WF}}$ ). Comparison of P RF $\mathbb {P}^{\text {RF}}$ against conventional P WH $\mathbb {P}^{\text {WH}}$ revealed that targeted focal brachytherapy would result in a marked reduction in dosage to the OARs while ensuring that the prescribed dose is delivered to the lesions. P WF $\mathbb {P}^{\text {WF}}$ resulted in only a marginal increase in dosage to the OARs compared to P WH $\mathbb {P}^{\text {WH}}$ . A similar trend was observed in case of EBRT with P RF $\mathbb {P}^{\text {RF}}$ and P WF $\mathbb {P}^{\text {WF}}$ compared to P WH $\mathbb {P}^{\text {WH}}$ . Conclusions A radiotherapy planning framework to generate targeted focal treatment plans has been presented. The focal treatment plans generated using the framework showed reduction in dosage to the organs at risk and a boosted dose delivered to the cancerous lesions.
Related Links	https://ro-journal.biomedcentral.com/counter/pdf/10.1186/s13014-016-0718-3.pdf
Ending Page	14
Page Count	14
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13014-016-0718-3
Journal	Radiation Oncology
Issue Number	1
Volume Number	11
Language	English
Publisher	BioMed Central
Publisher Date	2016-11-10
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Radiotherapy Imaging Radiology Treatment planning Computer aided diagnosis (CAD) Radiomics prostate cancer
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Oncology
Journal Impact Factor	3.3/2023
5-Year Journal Impact Factor	3.6/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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