| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Contreras-Cornejo, Humberto Saucedo-Correa, Germán Oviedo-Boyso, Javier Valdez-Alarcón, Juan José Baizabal-Aguirre, Víctor Manuel Cajero-Juárez, Marcos Bravo-Patiño, Alejandro |
| Abstract | The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involved in cell fate decision throughout development. This activity relies notably on the CSL proteins, (an acronym for CBF-1/RBPJ-κ in Homo sapiens/Mus musculus respectively, Suppressor of Hairless in Drosophila melanogaster, Lag-1 in Caenorhabditis elegans) which is the unique transcription factor and DNA binding protein involved in this pathway. The CSL proteins have the capacity to recruit activation or repression complexes according to the cellular context. The aim of this review is to describe the different co-repressor proteins that interact directly with CSL proteins to form repression complexes thereby regulating the Notch signaling pathway in animal cells to give insights into the paralogous evolution of these co-repressors in higher eumetazoans and their subsequent effects at developmental processes. |
| Related Links | https://celldiv.biomedcentral.com/counter/pdf/10.1186/s13008-016-0025-2.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17471028 |
| DOI | 10.1186/s13008-016-0025-2 |
| Journal | Cell Division |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2016-09-27 |
| Access Restriction | Open |
| Subject Keyword | Cell Biology Cancer Research Notch signaling pathway CSL Hairless Negative regulation Embryo development |
| Content Type | Text |
| Resource Type | Review |
| Subject | Biochemistry Molecular Biology Cell Biology |
| Journal Impact Factor | 2.8/2023 |
| 5-Year Journal Impact Factor | 3.1/2023 |
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