NDLI: Protective effect and related mechanisms of curcumin in rat experimental periodontitis

Content Provider	Springer Nature : BioMed Central
Author	Xiao, Chang-Jie Yu, Xi-Jiao Xie, Jian-Li Liu, Shuang Li, Shu
Abstract	Background Curcumin exhibits anti-inflammatory effects and has been suggested as a treatment for inflammatory diseases. The aim of this study was to investigate the effects of curcumin on the lipopolysaccharide induced inflammatory response in rat gingival fibroblasts in vitro and ligation-induced experimental periodontitis in vivo, and to speculate the possible anti-inflammatory mechanism of curcumin. Methods The gingival fibroblasts were incubated with different concentrations of curcumin in the absence or presence of lipopolysaccharide (LPS). Concentrations of interleukin-1β(IL-1β), tumor necrosis factor-α (TNF-α), osteoprotegerin (OPG) and soluble receptor activator of nuclear factor kappa-B ligand (RANKL) culture supernatants of rat gingival fibroblasts were determined by enzyme linked immunosorbent assay. The nuclear fraction of rat gingival fibroblasts was extracted and nuclear factor kappa-B (NF-κB) activation was assessed by western blotting to elucidate related mechanisms. Curcumin was given every two days by oral gavage. The gingival inflammation and alveolar bone loss between the first and second molars were observed by hematoxylin and eosin staining. Collagen fibers were observed by picro-sirius red staining. Alveolar bone loss was assessed by micro-CT analysis. Results Curcumin attenuated the production of IL-1β and TNF-α in rat gingival fibroblasts stimulated by LPS, and inhibited the LPS-induced decrease in OPG/sRANKL ratio and NF-κB activation. Curcumin significantly reduced gingival inflammation and modulated collagen fiber and alveolar bone loss in vivo. Conclusions curcumin modulates inflammatory activity in rat periodontitis by inhibiting NF-κB activation and decreasing the OPG/sRANKL ratio induced by LPS.
Related Links	https://head-face-med.biomedcentral.com/counter/pdf/10.1186/s13005-018-0169-1.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13005-018-0169-1
Journal	Head & Face Medicine
Issue Number	1
Volume Number	14
Language	English
Publisher	BioMed Central
Publisher Date	2018-08-16
Access Restriction	Open
Subject Keyword	Otorhinolaryngology Oral and Maxillofacial Surgery Dentistry Head and Neck Surgery Curcumin NF-κB OPG/RANKL Periodontitis Micro-CT
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Neurology (clinical) Dentistry
Journal Impact Factor	2.4/2023
5-Year Journal Impact Factor	2.9/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Head & Face Medicine

Reviewer acknowledgment

The orthodontic implant site-switching technique: a preliminary study in dogs

Trick or treat?

New paradigm in implant osseointegration

Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio

The expression levels of MicroRNA-146a, RANKL and OPG after non-surgical periodontal treatment

Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues

Clinical presentation and characteristics of lymphoma in the head and neck region

Protective effect and related mechanisms of curcumin in rat experimental periodontitis

Similar Documents

Head & Face Medicine

Reviewer acknowledgment

The orthodontic implant site-switching technique: a preliminary study in dogs

Trick or treat?

New paradigm in implant osseointegration

Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio

The expression levels of MicroRNA-146a, RANKL and OPG after non-surgical periodontal treatment

Regulation of somatostatin receptor 2 by proinflammatory, microbial and obesity-related signals in periodontal cells and tissues

Clinical presentation and characteristics of lymphoma in the head and neck region

Protective effect and related mechanisms of curcumin in rat experimental periodontitis