| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Danaher, Jessica Stathis, Christos G. Wilson, Robin A. Moreno-Asso, Alba Wellard, R. Mark Cooke, Matthew B. |
| Abstract | Background Physical exercise and activity status may modify the effect of the fat mass- and obesity-associated (FTO) genotype on body weight and obesity risk. To understand the interaction between FTO’s effect and physical activity, the present study investigated the effects of high and low intensity exercise on FTO mRNA and protein expression, and potential modifiers of exercise-induced changes in FTO in healthy-weighted individuals. Methods Twenty-eight untrained males and females (25.4 ± 1.1 years; 73.1 ± 2.0 kg; 178.8 ± 1.4 cm; 39.0 ± 1.2 ml.kg.min− 1 VO2peak) were genotyped for the FTO rs9939609 (T > A) polymorphism and performed isocaloric (400 kcal) cycle ergometer exercise on two separate occasions at different intensities: 80% (High Intensity (HI)) and 40% (Low Intensity (LO)) VO2peak. Skeletal muscle biopsies (vastus lateralis) and blood samples were taken pre-exercise and following 10 and 90 mins passive recovery. Results FTO mRNA expression was significantly decreased after HI intensity exercise (p = 0.003). No differences in basal and post-exercise FTO protein expression were evident between FTO genotypes. Phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and Akt substrate of 160 kDa (AS160) were significantly increased following HI intensity exercise (p < 0.05). Multivariate models of metabolomic data (orthogonal two partial least squares discriminant analysis (O2PLS-DA)) were unable to detect any significant metabolic differences between genotypes with either exercise trial (p > 0.05). However, skeletal muscle glucose accumulation at 10 mins following HI (p = 0.021) and LO (p = 0.033) intensity exercise was greater in AA genotypes compared to TT genotypes. Conclusion Our novel data provides preliminary evidence regarding the effects of exercise on FTO expression in skeletal muscle. Specifically, high intensity exercise downregulates expression of FTO mRNA and suggests that in addition to nutritional regulation, FTO could also be regulated by exercise. Trial registration ACTRN12612001230842 . Registered 21 November 2012 – Prospectively registered, https://www.anzctr.org.au/ |
| Related Links | https://nutritionandmetabolism.biomedcentral.com/counter/pdf/10.1186/s12986-020-00489-1.pdf |
| Ending Page | 14 |
| Page Count | 14 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17437075 |
| DOI | 10.1186/s12986-020-00489-1 |
| Journal | Nutrition & Metabolism |
| Issue Number | 1 |
| Volume Number | 17 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2020-08-17 |
| Access Restriction | Open |
| Subject Keyword | Clinical Nutrition Metabolic Diseases FTO Exercise Skeletal muscle Expression Metabolomics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Endocrinology, Diabetes and Metabolism Nutrition and Dietetics |
| Journal Impact Factor | 3.9/2023 |
| 5-Year Journal Impact Factor | 4.3/2023 |
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