NDLI: High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits

Content Provider	Springer Nature : BioMed Central
Author	Ning, Bo Wang, Xiaoyan Yu, Ying Waqar, Ahmed Bilal Yu, Qi Koike, Tomonari Shiomi, Masashi Liu, Enqi Wang, Yifei Fan, Jianglin
Abstract	Background Individuals with insulin resistance and resulting impaired glucose tolerance along with type 2 diabetes showed an increased prevalence of atherosclerosis. Our aim in this study was to address whether diet-induced insulin resistance plays any roles in the development of aortic and coronary atherosclerosis in hyperlipidemic rabbits. Methods We fed Watanabe heritable hyperlipidemic (WHHL) rabbits with a high-fructose and high-fat diet (HFFD) with restricted normal calories and compared the lesions of both aortic and coronary atherosclerosis with those of control WHHL rabbits fed a normal chow diet. Results HFFD-fed WHHL rabbits showed insulin resistance and impaired glucose tolerance accompanied by elevated plasma lipid levels and accumulation of adipose tissue even though their body weight was unchanged compared to the control rabbits. At 8 weeks, the aortic gross lesion area of HFFD-fed WHHL rabbits was increased by 40 % over the controls and their lesions were characterized by increased number of macrophages and smooth muscle cells. At 16 weeks, the lesions of HFFD-fed WHHL rabbits showed more advanced lesions such as lipid core formation and calcification. In addition, coronary atherosclerosis was significantly increased in HFFD-fed WHHL rabbits. Conclusions These results suggest that insulin resistance accelerates lesion formation of atherosclerosis.
Related Links	https://nutritionandmetabolism.biomedcentral.com/counter/pdf/10.1186/s12986-015-0024-3.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	17437075
DOI	10.1186/s12986-015-0024-3
Journal	Nutrition & Metabolism
Issue Number	1
Volume Number	12
Language	English
Publisher	BioMed Central
Publisher Date	2015-08-12
Access Restriction	Open
Subject Keyword	Clinical Nutrition Metabolic Diseases Insulin Resistance Coronary Atherosclerosis Cholesteryl Ester Transfer Protein Microsomal Triglyceride Transfer Protein Advanced Lesion
Content Type	Text
Resource Type	Article
Subject	Medicine Endocrinology, Diabetes and Metabolism Nutrition and Dietetics
Journal Impact Factor	3.9/2023
5-Year Journal Impact Factor	4.3/2023

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