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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Yao, Min Cheng, Zhirong Li, Xueyun Li, Yuexiang Ye, Wei Zhang, Hui Liu, He Zhang, Liang Lei, Yingfeng Zhang, Fanglin Lv, Xin |
| Abstract | N6-methyladenosine (m6A) is present in diverse viral RNA and plays important regulatory roles in virus replication and host antiviral innate immunity. However, the role of m6A in regulating JEV replication has not been investigated. Here, we show that the JEV genome contains m6A modification upon infection of mouse neuroblast cells (neuro2a). JEV infection results in a decrease in the expression of m6A writer METTL3 in mouse brain tissue. METTL3 knockdown by siRNA leads to a substantial decrease in JEV replication and the production of progeny viruses at 48 hpi. Mechanically, JEV triggered a considerable increase in the innate immune response of METTL3 knockdown neuro2a cells compared to the control cells. Our study has revealed the distinctive m6A signatures of both the virus and host in neuro2a cells infected with JEV, illustrating the positive role of m6A modification in JEV infection. Our study further enhances understanding of the role of m6A modification in Flaviviridae viruses. |
| Related Links | https://virologyj.biomedcentral.com/counter/pdf/10.1186/s12985-023-02275-w.pdf |
| Ending Page | 14 |
| Page Count | 14 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12985-023-02275-w |
| Journal | Virology Journal |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-01-19 |
| Access Restriction | Open |
| Subject Keyword | Virology Flavivirida Japanese encephalitis virus N6-Methyladenosine modification MeRIP-seq METTL3 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Infectious Diseases |
| Journal Impact Factor | 4/2023 |
| 5-Year Journal Impact Factor | 3.8/2023 |
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