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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Baroncelli, Silvia Galluzzo, Clementina Maria Liotta, Giuseppe Andreotti, Mauro Orlando, Stefano Ciccacci, Fausto Mphwere, Robert Luhanga, Richard Sagno, Jean Baptiste Amici, Roberta Marazzi, Maria Cristina Giuliano, Marina |
| Abstract | Background In sub-Saharan African countries Epstein Barr virus (EBV) infection occurs in early childhood. We aim to investigate the factors associated with EBV acquisition and the impact of EBV infection on the humoral response to HBV vaccination in infants born from HIV-positive, antiretroviral-treated mothers in Malawi. Methods A total of 149 HIV-exposed infants were included in this longitudinal study. EBV anti-VCA IgG were measured using an ELISA assay. The EBV seroconversion was correlated with the maternal viro-immunological conditions, with infant growth and immunological vulnerability, and with the humoral response to the HBV vaccine. Results No infant was EBV-positive at 6 months (n. 52 tested). More than a third of infants (49/115 or 42.6 %) on study beyond 6 months seroconverted at 12 months. At 24 months, out of 66 tested infants, only 13 remained EBV-uninfected, while 53 (80.3 %) acquired EBV infection, rising the total proportion of EBV seroconversion to 88.7 % (102/115 infants). EBV seroconversion was significantly associated with a low maternal educational status but had no impact on infant growth or vulnerability to infections. Reduced HBsAb levels and accelerated waning of antibodies were associated with early EBV seroconversion. Conclusions We found a heterogeneous timing of acquisition of EBV with the majority of infants born from HIV + mothers acquiring infection after 6 months. Anti-HBs levels were lower and appeared to wane faster in infants acquiring EBV infection. |
| Related Links | https://aidsrestherapy.biomedcentral.com/counter/pdf/10.1186/s12981-021-00375-7.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17426405 |
| DOI | 10.1186/s12981-021-00375-7 |
| Journal | AIDS Research and Therapy |
| Issue Number | 1 |
| Volume Number | 18 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-08-04 |
| Access Restriction | Open |
| Subject Keyword | Infectious Diseases Virology HIV exposed uninfected infants EBV acquisition response to HBV vaccine Malawi |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Medicine Virology Pharmacology (medical) |
| Journal Impact Factor | 2.1/2023 |
| 5-Year Journal Impact Factor | 2.4/2023 |
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