| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Yu, Lian Liu, Miao-Miao Guan, Mei-Qi Wang, Rui Yang, Xiao-Rong Zhang, Xiu-Min Wei, Jing-Jing Wu, Shu-Fen Gu, Hong Fu, Qiang Guo, Jun-Hong Li, Yan-Li |
| Abstract | Cognitive decline is a critical hallmark of brain aging. Although aging is a natural process, there is significant heterogeneity in cognition levels among individuals; however, the underlying mechanisms remain uncertain. In our study, we classified aged male Sprague‒Dawley rats into aged cognition-unimpaired (AU) group and aged cognition-impaired (AI) group by using an attentional set-shifting task. The transcriptome sequencing results of medial prefrontal cortex (mPFC) demonstrated significant differences in microglial activation and inflammatory response pathways between the two groups. Specifically, compared to AU rats, AI rats exhibited a greater presence of CD86-positive microglia and major histocompatibility complex class II (MHC-II)-positive microglia, along with elevated inflammatory molecules, in mPFC. Conversely, AI rats exhibited a reduction in the percentage of microglia expressing CD200R and the anti-inflammatory molecules Arg-1 and TGF-β. Additionally, peripheral blood analysis of AI rats demonstrated elevated levels of Th17 and Th1 cells, along with proinflammatory molecules; however, decreased levels of Treg cells, along with anti-inflammatory molecules, were observed in AI rats. Our research suggested that peripheral Th17/Treg cells and central microglial activation were associated with cognitive heterogeneity in aged rats. These findings may provide a new target for healthy aging. |
| Related Links | https://immunityageing.biomedcentral.com/counter/pdf/10.1186/s12979-024-00486-5.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17424933 |
| DOI | 10.1186/s12979-024-00486-5 |
| Journal | Immunity & Ageing |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-11-14 |
| Access Restriction | Open |
| Subject Keyword | Immunology Geriatrics Gerontology Aging Public Health Clinical Nutrition Antibodies Aging-associated cognitive decline Cognitive heterogeneity Microglial activation Th17/Treg cells Inflammation Geriatrics/Gerontology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Aging Immunology |
| Journal Impact Factor | 5.2/2023 |
| 5-Year Journal Impact Factor | 6.4/2023 |
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