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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Davinelli, Sergio Maes, Michael Corbi, Graziamaria Zarrelli, Armando Willcox, Donald Craig Scapagnini, Giovanni |
| Abstract | An extensive literature describes the positive impact of dietary phytochemicals on overall health and longevity. Dietary phytochemicals include a large group of non-nutrients compounds from a wide range of plant-derived foods and chemical classes. Over the last decade, remarkable progress has been made to realize that oxidative and nitrosative stress (O&NS) and chronic, low-grade inflammation are major risk factors underlying brain aging. Accumulated data strongly suggest that phytochemicals from fruits, vegetables, herbs, and spices may exert relevant negative immunoregulatory, and/or anti-O&NS activities in the context of brain aging. Despite the translational gap between basic and clinical research, the current understanding of the molecular interactions between phytochemicals and immune-inflammatory and O&NS (IO&NS) pathways could help in designing effective nutritional strategies to delay brain aging and improve cognitive function. This review attempts to summarise recent evidence indicating that specific phytochemicals may act as positive modulators of IO&NS pathways by attenuating pro-inflammatory pathways associated with the age-related redox imbalance that occurs in brain aging. We will also discuss the need to initiate long-term nutrition intervention studies in healthy subjects. Hence, we will highlight crucial aspects that require further study to determine effective physiological concentrations and explore the real impact of dietary phytochemicals in preserving brain health before the onset of symptoms leading to cognitive decline and inflammatory neurodegeneration. |
| Related Links | https://immunityageing.biomedcentral.com/counter/pdf/10.1186/s12979-016-0070-3.pdf |
| Ending Page | 17 |
| Page Count | 17 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17424933 |
| DOI | 10.1186/s12979-016-0070-3 |
| Journal | Immunity & Ageing |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2016-04-14 |
| Access Restriction | Open |
| Subject Keyword | Immunology Geriatrics Gerontology Aging Public Health Clinical Nutrition Antibodies Brain Diet Phytochemicals Inflammation Oxidative stress Geriatrics/Gerontology |
| Content Type | Text |
| Resource Type | Review |
| Subject | Aging Immunology |
| Journal Impact Factor | 5.2/2023 |
| 5-Year Journal Impact Factor | 6.4/2023 |
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