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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Tartour, Kevin Appourchaux, Romain Gaillard, Julien Nguyen, Xuan-Nhi Durand, Stéphanie Turpin, Jocelyn Beaumont, Elodie Roch, Emmanuelle Berger, Gregory Mahieux, Renaud Brand, Denys Roingeard, Philippe Cimarelli, Andrea |
| Abstract | Background Interferon induced transmembrane proteins 1, 2 and 3 (IFITMs) belong to a family of highly related antiviral factors that have been shown to interfere with a large spectrum of viruses including Filoviruses, Coronaviruses, Influenza virus, Dengue virus and HIV-1. In all these cases, the reported mechanism of antiviral inhibition indicates that the pool of IFITM proteins present in target cells blocks incoming viral particles in endosomal vesicles where they are subsequently degraded. Results In this study, we describe an additional mechanism through which IFITMs block HIV-1. In virus-producing cells, IFITMs coalesce with forming virions and are incorporated into viral particles. Expression of IFITMs during virion assembly leads to the production of virion particles of decreased infectivity that are mostly affected during entry in target cells. This mechanism of inhibition is exerted against different retroviruses and does not seem to be dependent on the type of Envelope present on retroviral particles. Conclusions The results described here identify a novel mechanism through which IFITMs affect HIV-1 infectivity during the late phases of the viral life cycle. Put in the context of data obtained by other laboratories, these results indicate that IFITMs can target HIV at two distinct moments of its life cycle, in target cells as well as in virus-producing cells. These results raise the possibility that IFITMs could similarly affect distinct steps of the life cycle of a number of other viruses. |
| Related Links | https://retrovirology.biomedcentral.com/counter/pdf/10.1186/s12977-014-0103-y.pdf |
| Ending Page | 14 |
| Page Count | 14 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17424690 |
| DOI | 10.1186/s12977-014-0103-y |
| Journal | Retrovirology |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2014-11-25 |
| Access Restriction | Open |
| Subject Keyword | Virology Infectious Diseases Cancer Research Vaccine Antibodies Protein Structure HIV IFITMs Restriction factors Interferon |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology |
| Journal Impact Factor | 2.7/2023 |
| 5-Year Journal Impact Factor | 3.1/2023 |
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