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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Wang, Wendi Lei, Wei Jiang, Lina Gao, Siqi Hu, Shijun Zhao, Zi-Gang Niu, Chun-Yu Zhao, Zhen-Ao |
| Abstract | The mortality rate of critically ill patients with acute respiratory distress syndrome (ARDS) is 30.9% to 46.1%. The emergence of the coronavirus disease 2019 (Covid-19) has become a global issue with raising dire concerns. Patients with severe Covid-19 may progress toward ARDS. Mesenchymal stem cells (MSCs) can be derived from bone marrow, umbilical cord, adipose tissue and so on. The easy accessibility and low immunogenicity enable MSCs for allogeneic administration, and thus they were widely used in animal and clinical studies. Accumulating evidence suggests that mesenchymal stem cell infusion can ameliorate ARDS. However, the underlying mechanisms of MSCs need to be discussed. Recent studies showed MSCs can modulate immune/inflammatory cells, attenuate endoplasmic reticulum stress, and inhibit pulmonary fibrosis. The paracrine cytokines and exosomes may account for these beneficial effects. In this review, we summarize the therapeutic mechanisms of MSCs in ARDS, analyzed the most recent animal experiments and Covid-19 clinical trial results, discussed the adverse effects and prospects in the recent studies, and highlight the potential roles of MSC therapy for Covid-19 patients with ARDS. |
| Related Links | https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-021-02862-x.pdf |
| Ending Page | 13 |
| Page Count | 13 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14795876 |
| DOI | 10.1186/s12967-021-02862-x |
| Journal | Journal of Translational Medicine |
| Issue Number | 1 |
| Volume Number | 19 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-05-10 |
| Access Restriction | Open |
| Subject Keyword | Biomedicine Medicine Public Health Mesenchymal stem cells Covid-19 Acute respiratory distress syndrome Medicine/Public Health |
| Content Type | Text |
| Resource Type | Review |
| Subject | Biochemistry, Genetics and Molecular Biology Medicine |
| Journal Impact Factor | 6.1/2023 |
| 5-Year Journal Impact Factor | 6.3/2023 |
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