NDLI: The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development

Content Provider	Springer Nature : BioMed Central
Author	Zhao, Baimei Nepovimova, Eugenie Wu, Qinghua
Abstract	The complex interaction between circadian rhythms and physiological functions is essential for maintaining human health. At the heart of this interaction lies the PERIOD proteins (PERs), pivotal to the circadian clock, influencing the timing of physiological and behavioral processes and impacting oxidative stress, immune functionality, and tumorigenesis. PER1 orchestrates the cooperation of the enzyme GPX1, modulating mitochondrial dynamics in sync with daily rhythms and oxidative stress, thus regulating the mechanisms managing energy substrates. PERs in innate immune cells modulate the temporal patterns of NF-κB and TNF-α activities, as well as the response to LPS-induced toxic shock, initiating inflammatory responses that escalate into chronic inflammatory conditions. Crucially, PERs modulate cancer cell behaviors including proliferation, apoptosis, and migration by influencing the levels of cell cycle proteins and stimulating the expression of oncogenes c-Myc and MDM2. PER2/3, as antagonists in cancer stem cell biology, play important roles in differentiating cancer stem cells and in maintaining their stemness. Importantly, the expression of Pers serve as a significant factor for early cancer diagnosis and prognosis. This review delves into the link between circadian rhythm regulator PERs, disruptions in circadian rhythm, and oncogenesis. We examine the evidence that highlights how dysfunctions in PERs activities initiate cancer development, aid tumor growth, and modify cancer cell metabolism through pathways involved in oxidative stress and immune system. Comprehending these connections opens new pathways for the development of circadian rhythm-based therapeutic strategies, with the aims of boosting immune responses and enhancing cancer treatments.
Related Links	https://biosignaling.biomedcentral.com/counter/pdf/10.1186/s12964-025-02040-2.pdf
Ending Page	29
Page Count	29
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12964-025-02040-2
Journal	Cell Communication and Signaling
Issue Number	1
Volume Number	23
Language	English
Publisher	BioMed Central
Publisher Date	2025-01-16
Access Restriction	Open
Subject Keyword	Cell Biology Protein-Ligand Interactions Receptors Cytokines and Growth Factors Circadian rhythms PERs Oxidative stress Immune response Cancer
Content Type	Text
Resource Type	Review
Subject	Biochemistry Cell Biology Molecular Biology
Journal Impact Factor	8.2/2023
5-Year Journal Impact Factor	8/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Circadian clock: a regulator of the immunity in cancer

Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis

The role of mitophagy in innate immune responses triggered by mitochondrial stress

Role of autophagy on cancer immune escape

Interplay of oxidative stress, cellular communication and signaling pathways in cancer

Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers

Endoplasmic reticulum stress targeted therapy for breast cancer

Metabolism of asparagine in the physiological state and cancer

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development

Similar Documents

Circadian clock: a regulator of the immunity in cancer

Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis

The role of mitophagy in innate immune responses triggered by mitochondrial stress

Role of autophagy on cancer immune escape

Interplay of oxidative stress, cellular communication and signaling pathways in cancer

Endogenous estrogen metabolites as oxidative stress mediators and endometrial cancer biomarkers

Endoplasmic reticulum stress targeted therapy for breast cancer

Metabolism of asparagine in the physiological state and cancer

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development