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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Nafissi, Nahid Mohammadlou, Maryam Akbari, Mohammad Esmaeil Mahdavi, Seyed Rabie Sheikh, Maryam Borji, Mohammad Babaee, Ebrahim Baharlou, Rasoul |
| Abstract | Objective Angiogenesis is one of the hallmarks of cancers that is involved in tumor progression. Angiogenic factors induce the formation of new blood vessels and tumor extension, and finally reduce the survival of patients. Intraoperative radiotherapy (IORT), in which radiation is delivered to the tumor bed can kill cells and change tumor microenvironment. Here, we compared the impact of IORT on the levels of angiogenic factors in the blood and surgical wound fluids (SWF) of the breast cancer patients. Patients and methods Three hundred sixty patients, who had undergone breast-conserving surgery between 2013 and 2018, were enrolled in IORT and non-IORT groups non-randomly. Blood and drained wound fluid (WF) samples were collected from the patients before and after surgery, followed by quantification of the amounts of TGF-β, EGF, FGF, VEGF, and DLL4 in the patients using ELISA. Results Our results were indicative of significant differences between the pre-surgery and post-surgery serum levels of EGF, DLL4, and VEGF. Furthermore, ROC analyses showed that TGF-β and DLL4 can differentiate of the early-stage from late-stage of the disease. Interestingly, the rate of the death and recurrence was reduced in IORT group. Conclusions In summary, IORT is a safe and effective treatment that can affect angiogenic factors and improve the overall- and recurrence-free survival of breast cancer patients. |
| Related Links | https://wjso.biomedcentral.com/counter/pdf/10.1186/s12957-022-02653-8.pdf |
| Ending Page | 8 |
| Page Count | 8 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14777819 |
| DOI | 10.1186/s12957-022-02653-8 |
| Journal | World Journal of Surgical Oncology |
| Issue Number | 1 |
| Volume Number | 20 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2022-06-09 |
| Access Restriction | Open |
| Subject Keyword | Surgical Oncology IORT TGF-β EGF FGF VEGF DLL4 Breast cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology Surgery |
| Journal Impact Factor | 2.5/2023 |
| 5-Year Journal Impact Factor | 2.8/2023 |
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