NDLI: Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection

Content Provider	Springer Nature : BioMed Central
Author	Coya, Juan Manuel De Matteis, Laura Giraud-Gatineau, Alexandre Biton, Anne Serrano-Sevilla, Inés Danckaert, Anne Dillies, Marie-Agnès Gicquel, Brigitte De la Fuente, Jesus M. Tailleux, Ludovic
Abstract	Background Infectious diseases are still a leading cause of death and, with the emergence of drug resistance, pose a great threat to human health. New drugs and strategies are thus urgently needed to improve treatment efficacy and limit drug-associated side effects. Nanotechnology-based drug delivery systems are promising approaches, offering hope in the fight against drug resistant bacteria. However, how nanocarriers influence the response of innate immune cells to bacterial infection is mostly unknown. Results Here, we used Mycobacterium tuberculosis as a model of bacterial infection to examine the impact of mannose functionalization of chitosan nanocarriers (CS-NCs) on the human macrophage response. Both ungrafted and grafted CS-NCs were similarly internalized by macrophages, via an actin cytoskeleton-dependent process. Although tri-mannose ligands did not modify the capacity of CS-NCs to escape lysosomal degradation, they profoundly remodeled the response of M. tuberculosis-infected macrophages. mRNA sequencing showed nearly 900 genes to be differentially expressed due to tri-mannose grafting. Unexpectedly, the set of modulated genes was enriched for pathways involved in cell metabolism, particularly oxidative phosphorylation and sugar metabolism. Conclusions The ability to modulate cell metabolism by grafting ligands at the surface of nanoparticles may thus be a promising strategy to reprogram immune cells and improve the efficacy of encapsulated drugs.
Related Links	https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-018-0439-x.pdf
Ending Page	15
Page Count	15
Starting Page	1
File Format	HTM / HTML
ISSN	14773155
DOI	10.1186/s12951-018-0439-x
Journal	Journal of Nanobiotechnology
Issue Number	1
Volume Number	17
Language	English
Publisher	BioMed Central
Publisher Date	2019-01-25
Access Restriction	Open
Subject Keyword	Biotechnology Nanotechnology Molecular Medicine Mycobacterium tuberculosis Chitosan nanocarriers Surface grafting Macrophages Host response
Content Type	Text
Resource Type	Article
Subject	Bioengineering Pharmaceutical Science Medicine Applied Microbiology and Biotechnology Biomedical Engineering Molecular Medicine Nanoscience and Nanotechnology
Journal Impact Factor	10.6/2023
5-Year Journal Impact Factor	11.4/2023

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