NDLI: Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release

Content Provider	Springer Nature : BioMed Central
Author	Cheng, Zhongjun Chen, Xiaoliang Zhai, Dongliang Gao, Feiyan Guo, Tingwang Li, Wenfeng Hao, Shilei Ji, Jingou Wang, Bochu
Abstract	Background Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications and drug delivery. However, few reports have focused on the keratin-based mucoadhesive drug delivery system and their mechanisms of mucoadhesion. Thus, the mucoadhesion controlled kerateine (reduced keratin, KTN)/keratose (oxidized keratin, KOS) composite nanoparticles were prepared via adjusting the proportion of KTN and KOS to achieve controlled gastric mucoadhesion and drug release based on their different mucoadhesive abilities and pH-sensitive properties. Furthermore, the mechanisms of mucoadhesion for KTN and KOS were also investigated in the present study. Results The composite keratin nanoparticles (KNPs) with different mass ratio of KTN to KOS, including 100/0 (KNP-1), 75/25 (KNP-2), 50/50 (KNP-3), and 25/75 (KNP-4), displayed different drug release rates and gastric mucoadhesion capacities, and then altered the drug pharmacokinetic performances. The stronger mucoadhesive ability of nanoparticle could supply longer gastric retention time, indicating that KTN displayed a stronger mucoadhesion than that of KOS. Furthermore, the mechanisms of mucoadhesion for KTN and KOS at different pH conditions were also investigated. The binding between KTN and porcine gastric mucin (PGM) is dominated by electrostatic attractions and hydrogen bondings at pH 4.5, and disulfide bonds also plays a key role in the interaction at pH 7.4. While, the main mechanisms of KOS and PGM interactions are hydrogen bondings and hydrophobic interactions in pH 7.4 condition and were hydrogen bondings at pH 4.5. Conclusions The resulting knowledge offer an efficient strategy to control the gastric mucoadhesion and drug release of nano drug delivery systems, and the elaboration of mucoadhesive mechanism of keratins will enable the rational design of nanocarriers for specific mucoadhesive drug delivery.
Related Links	https://jnanobiotechnology.biomedcentral.com/counter/pdf/10.1186/s12951-018-0353-2.pdf
Ending Page	13
Page Count	13
Starting Page	1
File Format	HTM / HTML
ISSN	14773155
DOI	10.1186/s12951-018-0353-2
Journal	Journal of Nanobiotechnology
Issue Number	1
Volume Number	16
Language	English
Publisher	BioMed Central
Publisher Date	2018-03-19
Access Restriction	Open
Subject Keyword	Biotechnology Nanotechnology Molecular Medicine Kerateine Keratose Mucoadhesion Controlled drug release Bioavailability
Content Type	Text
Resource Type	Article
Subject	Bioengineering Pharmaceutical Science Medicine Applied Microbiology and Biotechnology Biomedical Engineering Molecular Medicine Nanoscience and Nanotechnology
Journal Impact Factor	10.6/2023
5-Year Journal Impact Factor	11.4/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy

Polymeric nanoparticles (PNPs) for oral delivery of insulin

Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Novel targeted siRNA-loaded hybrid nanoparticles: preparation, characterization and in vitro evaluation

Magnetic core-shell nanoparticles for drug delivery by nebulization

Anticancer drug-loaded multifunctional nanoparticles to enhance the chemotherapeutic efficacy in lung cancer metastasis

Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis

The role of lipid-based nano delivery systems on oral bioavailability enhancement of fenofibrate, a BCS II drug: comparison with fast-release formulations

Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release

Similar Documents

Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy

Polymeric nanoparticles (PNPs) for oral delivery of insulin

Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Novel targeted siRNA-loaded hybrid nanoparticles: preparation, characterization and in vitro evaluation

Magnetic core-shell nanoparticles for drug delivery by nebulization

Anticancer drug-loaded multifunctional nanoparticles to enhance the chemotherapeutic efficacy in lung cancer metastasis

Real time in vitro studies of doxorubicin release from PHEMA nanoparticles

Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis

The role of lipid-based nano delivery systems on oral bioavailability enhancement of fenofibrate, a BCS II drug: comparison with fast-release formulations

Development of keratin nanoparticles for controlled gastric mucoadhesion and drug release