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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Ling, Xiaoxuan Han, Yali Meng, Jinxue Zhong, Bohuan Chen, Jialong Zhang, He Qin, Jiheng Pang, Jing Liu, Linhua |
| Abstract | Extrachromosomal circular DNA (eccDNA) refers to a type of circular DNA that originate from but are likely independent of chromosomes. Due to technological advancements, eccDNAs have recently emerged as multifunctional molecules with numerous characteristics. The unique topological structure and genetic characteristics of eccDNAs shed new light on the monitoring, early diagnosis, treatment, and prediction of cancer. EccDNAs are commonly observed in both normal and cancer cells and function via different mechanisms in the stress response to exogenous and endogenous stimuli, aging, and carcinogenesis and in drug resistance during cancer treatment. The structural diversity of eccDNAs contributes to the function and numerical diversity of eccDNAs and thereby endows eccDNAs with powerful roles in evolution and in cancer initiation and progression by driving genetic plasticity and heterogeneity from extrachromosomal sites, which has been an ignored function in evolution in recent decades. EccDNAs show great potential in cancer, and we summarize the features, biogenesis, evaluated functions, functional mechanisms, related methods, and clinical utility of eccDNAs with a focus on their role in evolution and cancer. |
| Related Links | https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/s12943-021-01413-8.pdf |
| Ending Page | 15 |
| Page Count | 15 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14764598 |
| DOI | 10.1186/s12943-021-01413-8 |
| Journal | Molecular Cancer |
| Issue Number | 1 |
| Volume Number | 20 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-09-03 |
| Access Restriction | Open |
| Subject Keyword | Cancer Research Oncology Extrachromosomal circular DNA Evolution Cancer Function of eccDNA |
| Content Type | Text |
| Resource Type | Review |
| Subject | Oncology Molecular Medicine Cancer Research |
| Journal Impact Factor | 27.7/2023 |
| 5-Year Journal Impact Factor | 31.3/2023 |
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