NDLI: Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products

Content Provider	Springer Nature : BioMed Central
Author	Paege, Norman Feustel, Sabrina Marx-Stoelting, Philip
Abstract	Risk assessment (RA) of microbial secondary metabolites (SM) is part of the EU approval process for microbial active substances (AS) used in plant protection products (PPP). As the number of potentially produced microbial SM may be high for a certain microbial strain and existing information on the metabolites often are low, data gaps are frequently identified during the RA. Often, RA cannot conclusively clarify the toxicological relevance of the individual substances. This work presents data and RA conclusions on four metabolites, Beauvericin, 2,3-deepoxy-2,3-didehydro-rhizoxin (DDR), Leucinostatin A and Swainsonin in detail as examples for the challenging process of RA. To overcome the problem of incomplete assessment reports, RA of microbial AS for PPP is in need of new approaches. In view of the Next Generation Risk Assessment (NGRA), the combination of literature data, omic-methods, in vitro and in silico methods combined in adverse outcome pathways (AOPs) can be used for an efficient and targeted identification and assessment of metabolites of concern (MoC).
Related Links	https://ehjournal.biomedcentral.com/counter/pdf/10.1186/s12940-024-01092-0.pdf
Ending Page	14
Page Count	14
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12940-024-01092-0
Journal	Environmental Health
Issue Number	1
Volume Number	23
Language	English
Publisher	BioMed Central
Publisher Date	2024-06-04
Access Restriction	Open
Subject Keyword	Occupational Medicine Industrial Medicine Public Health Environmental Health Plant protection active substance Beauvericin 2,3-deepoxy-2,3-didehydro-rhizoxin Leucinostatin A Swainsonin Microbial secondary metabolites Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Review
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health
Journal Impact Factor	5.4/2023
5-Year Journal Impact Factor	6.7/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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