NDLI: Endocrine disruptors alter social behaviors and indirectly influence social hierarchies via changes in body weight

Content Provider	Springer Nature : BioMed Central
Author	Kim, Benjamin Colon, Eliezer Chawla, Shivansh Vandenberg, Laura N. Suvorov, Alexander
Abstract	Background In humans, the causal link between socioeconomic status (SES) and body weight (BW) is bidirectional, as chronic stress associated with low SES may increase risk of obesity and excess weight may worsen career opportunities resulting in lower SES. We hypothesize that environmental factors affecting BW and/or social stress might reprogram physiological and social trajectories of individuals. Objectives To analyze interactions between BW and social behaviors in mice perinatally exposed to one of several environmental endocrine disruptors. Methods CD-1 mice were fed 0.2 mg/kg BW/day tetrabromobisphenol-A (TBBPA), 2,2,4,4-tetrabromodiphenyl ether (BDE-47), bisphenol S (BPS), or oil (vehicle) from pregnancy day 8 through postpartum day 21. Three male offspring (triad) from each litter were housed together until week 15 and subjected to a Sociability Test and Tube Tests. Cages were then rearranged so that animals of the same social rank from the four exposure groups were housed together in tetrads. Social hierarchy in tetrads was again analyzed by Tube Tests. Results In Sociability Tests, the mean velocity of all exposed animals increased when they encountered a stranger mouse and less time was spent with conspecifics. BW and social dominance of animals in triads and tetrads were inversely associated. BDE-47 and BPS caused transient decreases in BW. Conclusions Developmental exposure to environmental xenobiotics shifted behavior towards increased anxiety and decreased interest in social interactions. Our mouse model reproduces negative associations between social hierarchy status and BW. These results suggest that manipulation of BW by endocrine disruptors may affect social ranking.
Related Links	https://ehjournal.biomedcentral.com/counter/pdf/10.1186/s12940-015-0051-6.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12940-015-0051-6
Journal	Environmental Health
Issue Number	1
Volume Number	14
Language	English
Publisher	BioMed Central
Publisher Date	2015-08-05
Access Restriction	Open
Subject Keyword	Occupational Medicine Industrial Medicine Public Health Environmental Health Body weight Social status Social dominance Sociability Endocrine disruption Tetrabromobisphenol-A TBBPA 2,2,4,4-tetrabromodiphenyl ether BDE-47 Bisphenol S BPS Occupational Medicine/Industrial Medicine
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health
Journal Impact Factor	5.4/2023
5-Year Journal Impact Factor	6.7/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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