NDLI: Hemodynamic effects of enhanced external counterpulsation on cerebral arteries: a multiscale study

Content Provider	Springer Nature : BioMed Central
Author	Li, Bao Wang, Wenxin Mao, Boyan Zhang, Yahui Chen, Sihan Yang, Haisheng Niu, Haijun Du, Jianhang Li, Xiaoling Liu, Youjun
Abstract	Background Enhanced external counterpulsation (EECP) is an effective method for treating patients with cerebral ischemic stroke, while hemodynamics is the major contributing factor in the treatment of EECP. Different counterpulsation modes have the potential to lead to different acute and long-term hemodynamic changes, resulting in different treatment effects. However, various questions about appropriate counterpulsation modes for optimizing hemodynamic effects remain unanswered in clinical treatment. Methods A zero-dimensional/three-dimensional (0D/3D) geometric multiscale model of the cerebral artery was established to obtain acute hemodynamic indicators, including mean arterial pressure (MAP) and cerebral blood flow (CBF), as well as localized hemodynamic details for the cerebral artery, which includes wall shear stress (WSS) and oscillatory shear index (OSI). Counterpulsation was achieved by applying pressure on calf, thigh and buttock modules in the 0D model. Different counterpulsation modes including various pressure amplitudes and pressurization durations were applied to investigate hemodynamic responses, which impact acute and long-term treatment effects. Both vascular collapse and cerebral autoregulation were considered during counterpulsation. Results Variations of pressure amplitude and pressurization duration have different impacts on hemodynamic effects during EECP treatment. There were small differences in the hemodynamics when similar or different pressure amplitudes were applied to calves, thighs and buttocks. When increasing pressure amplitude was applied to the three body parts, MAP and CBF improved slightly. When pressure amplitude exceeded 200 mmHg, hemodynamic indicators almost never changed, demonstrating consistency with clinical data. However, hemodynamic indicators improved significantly with increasing pressurization duration. For pressurization durations of 0.5, 0.6 and 0.7 s, percentage increases for MAP during counterpulsation were 1.5%, 23.5% and 39.0%, for CBF were 1.2%, 23.4% and 41.6% and for time-averaged WSS were 0.2%, 43.5% and 85.0%, respectively. Conclusions When EECP was applied to patients with cerebral ischemic stroke, pressure amplitude applied to the three parts may remain the same. Patients may not gain much more benefit from EECP treatment by excessively increasing pressure amplitude above 200 mmHg. However, during clinical procedures, pressurization duration could be increased to 0.7 s during the cardiac circle to optimize the hemodynamics for possible superior treatment outcomes.
Related Links	https://biomedical-engineering-online.biomedcentral.com/counter/pdf/10.1186/s12938-019-0710-x.pdf
Ending Page	24
Page Count	24
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s12938-019-0710-x
Journal	BioMedical Engineering OnLine
Issue Number	1
Volume Number	18
Language	English
Publisher	BioMed Central
Publisher Date	2019-08-28
Access Restriction	Open
Subject Keyword	Biomedical Engineering and Bioengineering Biomaterials Biotechnology Biomedical Engineering Enhanced external counterpulsation Cerebral artery Geometric multiscale model Mean arterial pressure Cerebral blood flow Wall shear stress Biomedical Engineering/Biotechnology
Content Type	Text
Resource Type	Article
Subject	Biomaterials Radiological and Ultrasound Technology Biomedical Engineering Radiology, Nuclear Medicine and Imaging
Journal Impact Factor	2.9/2023
5-Year Journal Impact Factor	3.5/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mining data from hemodynamic simulations via Bayesian emulation

Study of correlation between wall shear stress and elasticity in atherosclerotic carotid arteries

Computational model of blood flow in the aorto-coronary bypass graft

Influence of malformation of right coronary artery originating from the left sinus in hemodynamic environment

Influence of model boundary conditions on blood flow patterns in a patient specific stenotic right coronary artery

Pulsatile arterial wall-blood flow interaction with wall pre-stress computed using an inverse algorithm

Hemodynamics of Enhanced External Counterpulsation with Different Coronary Stenosis

Contrast-enhanced micro-CT imaging in murine carotid arteries: a new protocol for computing wall shear stress

The study on hemodynamic effect of series type LVAD on aortic blood flow pattern: a primary numerical study

Hemodynamic effects of enhanced external counterpulsation on cerebral arteries: a multiscale study

Similar Documents

Mining data from hemodynamic simulations via Bayesian emulation

Study of correlation between wall shear stress and elasticity in atherosclerotic carotid arteries

Computational model of blood flow in the aorto-coronary bypass graft

Influence of malformation of right coronary artery originating from the left sinus in hemodynamic environment

Influence of model boundary conditions on blood flow patterns in a patient specific stenotic right coronary artery

Pulsatile arterial wall-blood flow interaction with wall pre-stress computed using an inverse algorithm

Hemodynamics of Enhanced External Counterpulsation with Different Coronary Stenosis

Contrast-enhanced micro-CT imaging in murine carotid arteries: a new protocol for computing wall shear stress

The study on hemodynamic effect of series type LVAD on aortic blood flow pattern: a primary numerical study

Hemodynamic effects of enhanced external counterpulsation on cerebral arteries: a multiscale study