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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Frost, Samuel J. Mawad, Damia Wuhrer, Richard Myers, Simon Lauto, Antonio |
| Abstract | Background Extracellular matrices (ECMs) are often used in reconstructive surgery to enhance tissue regeneration and remodeling. Sutures and staples are currently used to fix ECMs to tissue although they can be invasive devices. Other sutureless and less invasive techniques, such as photochemical tissue bonding, cannot be coupled to ECMs because of their intrinsic opacity to light. Results We succeeded in fabricating a biocompatible and adhesive device that is based on ovine forestomach matrix (OFM) and a chitosan adhesive. The natural opacity of the OFM has been overcome by adding the adhesive into the matrix that allows for the light to effectively penetrate through it. The OFM-chitosan device is semitransparent (attenuation length ~ 106 µm) and can be photoactivated by green light to bond to tissue. This device does not require sutures or staples and guarantees a bonding strength of ~ 23 kPa. Conclusions A new semitransparent and biocompatible bandage has been successfully fabricated and characterized for sutureless tissue bonding. |
| Related Links | https://biomedical-engineering-online.biomedcentral.com/counter/pdf/10.1186/s12938-018-0444-1.pdf |
| Ending Page | 14 |
| Page Count | 14 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12938-018-0444-1 |
| Journal | BioMedical Engineering OnLine |
| Issue Number | 1 |
| Volume Number | 17 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2018-01-22 |
| Access Restriction | Open |
| Subject Keyword | Biomedical Engineering and Bioengineering Biomaterials Biotechnology Biomedical Engineering Tissue repair Lasers Adhesives Biopolymers Biomedical Engineering/Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biomaterials Radiological and Ultrasound Technology Biomedical Engineering Radiology, Nuclear Medicine and Imaging |
| Journal Impact Factor | 2.9/2023 |
| 5-Year Journal Impact Factor | 3.5/2023 |
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