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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Ndiaye, Yaye D. Wong, Wesley Thwing, Julie Schaffner, Stephen F. Brenneman, Katelyn Vendrely Tine, Abdoulaye Diallo, Mamadou A. Deme, Awa B. Sy, Mouhamad Bei, Amy K. Thiaw, Alphonse B. Daniels, Rachel Ndiaye, Tolla Gaye, Amy Ndiaye, Ibrahima M. Toure, Mariama Gadiaga, Nogaye Sene, Aita Sow, Djiby Garba, Mamane N. Yade, Mamadou S. Dieye, Baba Diongue, Khadim Zoumarou, Daba Ndiaye, Aliou Gomis, Jules F. Fall, Fatou B. Ndiop, Medoune Diallo, Ibrahima Sene, Doudou Macinnis, Bronwyn Seck, Mame C. Ndiaye, Mouhamadou Ngom, Bassirou Diedhiou, Younouss Mbaye, Amadou M. Ndiaye, Lamine Sy, Ngayo Badiane, Aida S. Hartl, Daniel L. Wirth, Dyann F. Volkman, Sarah K. Ndiaye, Daouda |
| Abstract | Background Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance. Methods Data from two decades (2000–2020) of continuous molecular surveillance of P. falciparum parasites from Senegal were retrospectively examined to assess historical changes in malaria drug resistance mutations. Several known drug resistance markers and their surrounding haplotypes were profiled using a combination of single nucleotide polymorphism (SNP) molecular surveillance and whole genome sequence based population genomics. Results This dataset was used to track temporal changes in drug resistance markers whose timing correspond to historically significant events such as the withdrawal of chloroquine (CQ) and the introduction of sulfadoxine-pyrimethamine (SP) in 2003. Changes in the mutation frequency at Pfcrt K76T and Pfdhps A437G coinciding with the 2014 introduction of seasonal malaria chemoprevention (SMC) in Senegal were observed. In 2014, the frequency of Pfcrt K76T increased while the frequency of Pfdhps A437G declined. Haplotype-based analyses of Pfcrt K76T showed that this rapid increase was due to a recent selective sweep that started after 2014. Discussion (Conclusion) The rapid increase in Pfcrt K76T is troubling and could be a sign of emerging amodiaquine (AQ) resistance in Senegal. Emerging AQ resistance may threaten the future clinical efficacy of artesunate-amodiaquine (ASAQ) and AQ-dependent SMC chemoprevention. These results highlight the potential of molecular surveillance for detecting rapid changes in parasite populations and stress the need to monitor the effectiveness of AQ as a partner drug for artemisinin-based combination therapy (ACT) and for chemoprevention. |
| Related Links | https://malariajournal.biomedcentral.com/counter/pdf/10.1186/s12936-024-05024-8.pdf |
| Ending Page | 14 |
| Page Count | 14 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752875 |
| DOI | 10.1186/s12936-024-05024-8 |
| Journal | Malaria Journal |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-07-09 |
| Access Restriction | Open |
| Subject Keyword | Parasitology Tropical Medicine Infectious Diseases Entomology Microbiology Public Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology |
| Journal Impact Factor | 2.4/2023 |
| 5-Year Journal Impact Factor | 2.6/2023 |
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