| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Martinez-Dominguez, Pavel Gomez-Aviles, Paola Bautista-García, Kenya Antonio-Villa, Neftali Eduardo Guerra, Enrique C. Almeda-Valdes, Paloma Martagón, Alexandro J. Munoz, Alejandro Campos Santa-Ana-Bayona, Maria Jose Alexanderson, Erick Salinas, Carlos A. Aguilar Espinola-Zavaleta, Nilda |
| Abstract | Background Adipose tissue distribution plays a crucial role in the development of cardiovascular complications. In particular, visceral adipose tissue (VAT) has been linked to insulin resistance (IR) and cardiovascular disease (CVD). However, the relationship between VAT, cardiac dysfunction and the meditation capacity of VAT related to IR has not been fully characterized. Methods This cross-sectional study included adults living with type 2 diabetes (T2D). VAT was measured using electrical bioimpedance and also estimated with the Metabolic Score for Visceral Fat (METS-VF). LV function was assessed using left ventricular global longitudinal strain (LV-GLS) by speckle tracking echocardiography analysis. Spearman correlation coefficients, adjusted linear regression models guided by direct acyclic diagrams and causal mediation analysis were performed. Results Among 195 adults living with T2D (median age: 57, IQR: 49–64, women: 63%), VAT showed a positive association with LV-GLS (β = 0.482, 95% CI: 0.060–0.904, p = 0.039) after adjusting for relevant confounders. The effect was strongly replicated using METS-VF as a surrogate for VAT. The mediation analysis revealed that VAT accounted for 60.9% (95% CI: 15.82–171) of the total effect between IR and LV-GLS. Conclusion This study demonstrated a positive association between VAT and LV-GLS. This relationship was consistently observed using the clinical surrogate METS-VF. Visceral adiposity was identified as a strong mediator in the relationship between IR and LV-GLS, underscoring its role in the pathophysiology of cardiovascular disease in patients with T2D. Graphical abstract Summary of the main results of the study. Abbreviations: T2D: Type 2 diabetes, LV-GLS, Left-ventricular global longitudinal strain; VAT: Visceral adipose tissue; METS-VF, Metabolic Score for Visceral Fat. |
| Related Links | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-024-02547-x.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752840 |
| DOI | 10.1186/s12933-024-02547-x |
| Journal | Cardiovascular Diabetology |
| Issue Number | 1 |
| Volume Number | 24 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2025-01-02 |
| Access Restriction | Open |
| Subject Keyword | Diabetes Angiology Cardiology Visceral adiposity Left ventricular dysfunction Type 2 diabetes Echocardiography Obesity Insulin resistance |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cardiology and Cardiovascular Medicine Internal Medicine Endocrinology, Diabetes and Metabolism |
| Journal Impact Factor | 8.5/2023 |
| 5-Year Journal Impact Factor | 8.9/2023 |
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