| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Hoehlschen, Julia Hofreither, Dominik Tomin, Tamara Birner-Gruenberger, Ruth |
| Abstract | Sodium-glucose co-transporter-2 inhibitors are used in the treatment of diabetes but are also emerging as cardioprotective agents in heart diseases even in the absence of type 2 diabetes. In this paper, upon providing a short overview of common pathophysiological features of diabetes, we review the clinically reported cardio- and nephroprotective potential of sodium-glucose co-transporter-2 inhibitors currently available on the market, including Dapagliflozin, Canagliflozin, and Empagliflozin. To that end, we summarize findings of clinical trials that have initially drawn attention to the drugs’ organ-protective potential, before providing an overview of their proposed mechanism of action. Since we particularly expect that their antioxidative properties will broaden the application of gliflozins from therapeutic to preventive care, special emphasis was put on this aspect. |
| Related Links | https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-023-01822-7.pdf |
| Ending Page | 10 |
| Page Count | 10 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 14752840 |
| DOI | 10.1186/s12933-023-01822-7 |
| Journal | Cardiovascular Diabetology |
| Issue Number | 1 |
| Volume Number | 22 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2023-04-29 |
| Access Restriction | Open |
| Subject Keyword | Diabetes Angiology Cardiology SGLT-2 Empagliflozin Canagliflozin Dapagliflozin Heart failure Oxidative stress |
| Content Type | Text |
| Resource Type | Review |
| Subject | Cardiology and Cardiovascular Medicine Internal Medicine Endocrinology, Diabetes and Metabolism |
| Journal Impact Factor | 8.5/2023 |
| 5-Year Journal Impact Factor | 8.9/2023 |
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