NDLI: In-hospital glycemic variability and all-cause mortality among patients hospitalized for acute heart failure

Content Provider	Springer Nature : BioMed Central
Author	Chun, Kyeong-Hyeon Oh, Jaewon Lee, Chan Joo Park, Jin Joo Lee, Sang Eun Kim, Min-Seok Cho, Hyun-Jai Choi, Jin-Oh Lee, Hae-Young Hwang, Kyung-Kuk Kim, Kye Hun Yoo, Byung-Su Choi, Dong-Ju Baek, Sang Hong Jeon, Eun-Seok Kim, Jae-Joong Cho, Myeong-Chan Chae, Shung Chull Oh, Byung-Hee Kang, Seok-Min
Abstract	Background High glycemic variability (GV) is a poor prognostic marker in cardiovascular diseases. We aimed to investigate the association of GV with all-cause mortality in patients with acute heart failure (HF). Methods The Korean Acute Heart Failure registry enrolled patients hospitalized for acute HF from 2011 to 2014. Blood glucose levels were measured at the time of admission, during hospitalization, and at discharge. We included those who had 3 or more blood glucose measurements in this study. Patients were divided into two groups based on the coefficient of variation (CoV) as an indicator of GV. Among survivors of the index hospitalization, we investigated all-cause mortality at 1 year after discharge. Results The study analyzed 2,617 patients (median age, 72 years; median left-ventricular ejection fraction, 36%; 53% male). During the median follow-up period of 11 months, 583 patients died. Kaplan–Meier curve analysis revealed that high GV (CoV > 21%) was associated with lower cumulative survival (log-rank P < 0.001). Multivariate Cox proportional analysis showed that high GV was associated with an increased risk of 1-year (HR 1.56, 95% CI 1.26–1.92) mortality. High GV significantly increased the risk of 1-year mortality in non-diabetic patients (HR 1.93, 95% CI 1.47–2.54) but not in diabetic patients (HR 1.19, 95% CI 0.86–1.65, P for interaction = 0.021). Conclusions High in-hospital GV before discharge was associated with all-cause mortality within 1 year, especially in non-diabetic patients with acute HF.
Related Links	https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-022-01720-4.pdf
Ending Page	12
Page Count	12
Starting Page	1
File Format	HTM / HTML
ISSN	14752840
DOI	10.1186/s12933-022-01720-4
Journal	Cardiovascular Diabetology
Issue Number	1
Volume Number	21
Language	English
Publisher	BioMed Central
Publisher Date	2022-12-27
Access Restriction	Open
Subject Keyword	Diabetes Angiology Cardiology Glucose metabolism disorder Glycemic variability Type 2 diabetes mellitus Heart failure Mortality
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Internal Medicine Endocrinology, Diabetes and Metabolism
Journal Impact Factor	8.5/2023
5-Year Journal Impact Factor	8.9/2023

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