NDLI: A genome-wide association study of methamphetamine use among people with HIV

Content Provider	Springer Nature : BioMed Central
Author	Venkataraman, A. Jia, T. Ruderman, S. A. Haas, C. B. Nance, R. M. Mixson, L. S. Mayer, K. H. Saag, M S Chander, G. Moore, R. D. Jacobson, J. Napravnik, S. Christopolous, K. Lee, W. J. Whitney, B. M. Peter, I. Crane, H. M. Delaney, J. A. C. Lindström, S.
Abstract	Background Amphetamine-like stimulants are the most used psychostimulants in the world; methamphetamine use is the most prevalent in people with HIV. Prolonged methamphetamine use can cause lasting damage to the heart, gut, and brain, as well as auditory hallucinations and paranoid thinking. However, relatively little is known about methamphetamine use and its genetic contributors. Methods Using genetic information from the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort, we conducted a multi-ancestry genome-wide association study (GWAS) of methamphetamine use among people with HIV (n = 1,196 reported ever use, n = 4,750 reported never use). Results No single nucleotide polymorphism was statistically associated with methamphetamine use at the genome-wide level (p < 5 * 10–8) in our study. Further, we did not replicate previously suggested genetic variants from other studies (all p > 0.05 in our analysis). Discussion Our study suggests that there is no single strong genetic contributor to lifetime use of methamphetamine in people with HIV enrolled in CNICS. Larger studies with more refined outcome assessment are warranted to further understand the contribution of genetics to methamphetamine use and use disorder. Investigation into social and environmental contributors to methamphetamine use are similarly necessary.
Related Links	https://bmcmedgenomics.biomedcentral.com/counter/pdf/10.1186/s12920-025-02105-8.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	17558794
DOI	10.1186/s12920-025-02105-8
Journal	BMC Medical Genomics
Issue Number	1
Volume Number	18
Language	English
Publisher	BioMed Central
Publisher Date	2025-03-11
Access Restriction	Open
Subject Keyword	Human Genetics Microarrays Gene Expression Methamphetamine Substance use GWAS HIV Genetic epidemiology Stimulant use
Content Type	Text
Resource Type	Article
Subject	Genetics (clinical) Genetics
Journal Impact Factor	2.1/2023
5-Year Journal Impact Factor	2.5/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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